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MarR DNA-binding transcriptional repressor

Synonyms: MarR, MarR-2,4-dinitrophenol, MarR-Benzoate, MarR-Menadione, MarR-Paraquat, MarR-Phenazine methosulfate, MarR-Plumbagin, MarR-salicylate, MarR-Sodium salicylate


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
MarR Functional   Apo [BPP], [GEA], [IPI] [1], [2], [3]
MarR-2,4-dinitrophenol Non-Functional Allosteric Holo [BPP], [GEA], [IPI] [1], [3]
MarR-Benzoate Non-Functional Allosteric Holo [BPP], [GEA] [3]
MarR-Menadione Non-Functional Allosteric Holo [BPP], [GEA], [IPI] [1], [3]
MarR-Paraquat Non-Functional Allosteric Holo [BPP], [GEA] [3]
MarR-Phenazine methosulfate Non-Functional Allosteric Holo [BPP], [GEA] [3]
MarR-Plumbagin Non-Functional Allosteric Holo [BPP], [GEA], [IPI] [1], [3]
MarR-Sodium salicylate Non-Functional Allosteric Holo [BPP], [IPI] [1]
MarR-salicylate Non-Functional Allosteric Holo [BPP], [GEA] [2], [3]
Evolutionary Family: MarR
Connectivity class: Local Regulator
Gene name: marR
  Genome position: 1619120-1619554
  Length: 435 bp / 144 aa
Operon name: marRAB
TU(s) encoding the TF:
Transcription unit        Promoter
marRAB
marRp


Regulon       
Regulated gene(s) marA, marB, marR
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
drug resistance/sensitivity (3)
Transcription related (2)
repressor (2)
operon (2)
detoxification (2)
Read more >
Regulated operon(s) marRAB
First gene in the operon(s) marR
Simple and complex regulons AcrR,CRP,CpxR,Cra,Fis,MarA,MarR,Rob,SoxS
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[MarR,-](1)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  MarR repressor marRp Sigma70 -18.0 -45.5 marR, marA, marB
catttgacttATACTTGCCTGGGCAATATTATcccctgcaac
1619064 1619085 [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [3], [4], [5], [6], [7], [8]
  MarR repressor marRp Sigma70 17.0 -11.5 marR, marA, marB
cctgcaactaATTACTTGCCAGGGCAACTAATgtgaaaagta
1619098 1619119 [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [3], [4], [5], [6], [7], [8]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [IPI] Inferred from physical interaction

 [AIBSCS] Automated inference based on similarity to consensus sequences

 [HIBSCS] Human inference based on similarity to consensus sequences

 [SM] Site mutation



Reference(s)    

 [1] Alekshun MN., Levy SB., 1999, Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro., J Bacteriol. 181(15):4669-72

 [2] Cohen SP., Levy SB., Foulds J., Rosner JL., 1993, Salicylate induction of antibiotic resistance in Escherichia coli: activation of the mar operon and a mar-independent pathway., J Bacteriol. 175(24):7856-62

 [3] Seoane AS., Levy SB., 1995, Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli., J Bacteriol. 177(12):3414-9

 [4] Cohen SP., Hachler H., Levy SB., 1993, Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli., J Bacteriol. 175(5):1484-92

 [5] Martin RG., Rosner JL., 2004, Transcriptional and translational regulation of the marRAB multiple antibiotic resistance operon in Escherichia coli., Mol Microbiol. 53(1):183-91

 [6] Martin RG., Rosner JL., 1995, Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences., Proc Natl Acad Sci U S A. 92(12):5456-60

 [7] Notka F., Linde HJ., Dankesreiter A., Niller HH., Lehn N., 2002, A C-terminal 18 amino acid deletion in MarR in a clinical isolate of Escherichia coli reduces MarR binding properties and increases the MIC of ciprofloxacin., J Antimicrob Chemother. 49(1):41-7

 [8] Rodionov DA., Gelfand MS., Mironov AA., Rakhmaninova AB., 2001, Comparative approach to analysis of regulation in complete genomes: multidrug resistance systems in gamma-proteobacteria., J Mol Microbiol Biotechnol. 3(2):319-24



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