RegulonDB RegulonDB 9.4:Regulon Page

MarR DNA-binding transcriptional repressor

Synonyms: MarR, MarR-2,4-dinitrophenol, MarR-Benzoate, MarR-Menadione, MarR-Paraquat, MarR-Phenazine methosulfate, MarR-Plumbagin, MarR-salicylate, MarR-Sodium salicylate

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
MarR Functional   Apo [BPP], [GEA], [IPI] [1], [2], [3]
MarR-2,4-dinitrophenol Non-Functional Allosteric Holo [BPP], [GEA], [IPI] [1], [3]
MarR-Benzoate Non-Functional Allosteric Holo [BPP], [GEA] [3]
MarR-Menadione Non-Functional Allosteric Holo [BPP], [GEA], [IPI] [1], [3]
MarR-Paraquat Non-Functional Allosteric Holo [BPP], [GEA] [3]
MarR-Phenazine methosulfate Non-Functional Allosteric Holo [BPP], [GEA] [3]
MarR-Plumbagin Non-Functional Allosteric Holo [BPP], [GEA], [IPI] [1], [3]
MarR-Sodium salicylate Non-Functional Allosteric Holo [BPP], [IPI] [1]
MarR-salicylate Non-Functional Allosteric Holo [BPP], [GEA] [2], [3]
Evolutionary Family: MarR
Connectivity class: Local Regulator
Gene name: marR
  Genome position: 1619120-1619554
  Length: 435 bp / 144 aa
Operon name: marRAB
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) marA, marB, marR
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
drug resistance/sensitivity (3)
Transcription related (2)
repressor (2)
operon (2)
detoxification (2)
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Regulated operon(s) marRAB
First gene in the operon(s) marR
Simple and complex regulons AcrR,CRP,CpxR,Cra,Fis,MarA,MarR,Rob,SoxS
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Growth Conditions Evidence (Confirmed, Strong, Weak) References
  MarR repressor marRp Sigma70 -18.0 -45.5 marR, marA, marB
1619064 1619085 [a] [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [3], [4], [5], [6], [7], [8]
  MarR repressor marRp Sigma70 17.0 -11.5 marR, marA, marB
1619098 1619119 [a] [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [3], [4], [5], [6], [7], [8]

Growth Condition    

 [a] Salicylate treatment

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [IPI] Inferred from physical interaction

 [AIBSCS] Automated inference based on similarity to consensus sequences

 [HIBSCS] Human inference based on similarity to consensus sequences

 [SM] Site mutation


 [1] Alekshun MN., Levy SB., 1999, Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro., J Bacteriol. 181(15):4669-72

 [2] Cohen SP., Levy SB., Foulds J., Rosner JL., 1993, Salicylate induction of antibiotic resistance in Escherichia coli: activation of the mar operon and a mar-independent pathway., J Bacteriol. 175(24):7856-62

 [3] Seoane AS., Levy SB., 1995, Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli., J Bacteriol. 177(12):3414-9

 [4] Cohen SP., Hachler H., Levy SB., 1993, Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli., J Bacteriol. 175(5):1484-92

 [5] Martin RG., Rosner JL., 2004, Transcriptional and translational regulation of the marRAB multiple antibiotic resistance operon in Escherichia coli., Mol Microbiol. 53(1):183-91

 [6] Martin RG., Rosner JL., 1995, Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences., Proc Natl Acad Sci U S A. 92(12):5456-60

 [7] Notka F., Linde HJ., Dankesreiter A., Niller HH., Lehn N., 2002, A C-terminal 18 amino acid deletion in MarR in a clinical isolate of Escherichia coli reduces MarR binding properties and increases the MIC of ciprofloxacin., J Antimicrob Chemother. 49(1):41-7

 [8] Rodionov DA., Gelfand MS., Mironov AA., Rakhmaninova AB., 2001, Comparative approach to analysis of regulation in complete genomes: multidrug resistance systems in gamma-proteobacteria., J Mol Microbiol Biotechnol. 3(2):319-24