During anaerobiosis, TdcA participates in controlling genes (tdc operon) involved in transport and metabolism of threonine and serine |CITS:|.
TdcA belongs to the LysR family of transcriptional regulators, and like the other members of this family, it has a helix-turn-helix motif in the N-terminal domain for DNA binding |CITS:|.
Although interaction between TdcA and the regulatory region of the tdc operon has not been demonstrated, it has been suggested that TdcA recognizes and binds to an inverted repeat located upstream of the operon |CITS:|.
tdcA is the first gene in the tdcABCDEFG operon, which is autoactivated by TdcA. This operon is divergently transcribed with the tdcR gene, whose product also activates the transcription of the operon |CITS:|. TdcA probably interacts with TdcR to activate transcription |CITS:|, and they appear to function together with CRP and IHF, proteins that bend the DNA, for this activation |CITS:|.
A mutation in the tdcA gene of enterohemorrhagic Escherichia coli O157:H7 causes the expression of OmpA protein which is involved, among several other processes, in cellular adherence |CITS:|.
tdc: threonine dehydratase |CITS:|.
|Sensing class:||Sensing external and internal signals|
|Connectivity class:||Local Regulator|
|Length:||939 bp / 312 aa|
|TU(s) encoding the TF:||
|Regulated gene(s)||tdcA, tdcB, tdcC, tdcD, tdcE, tdcF, tdcG|
|Multifun term(s) of regulated gene(s)||
MultiFun Term (List of genes associated to the multifun term)
amino acids (4)
tdcA, tdcB, tdcE, tdcG
threonine catabolism (3)
tdcB, tdcD, tdcE
Transcription related (1)
Porters (Uni-, Sym- and Antiporters) (1)
|First gene in the operon(s)||tdcA|
|Simple and complex regulons|
|Simple and complex regulatory phrases||
Regulatory phrase (List of promoters regulated by the phrase)
|Functional conformation||Function||Promoter||Sigma factor||Central Rel-Pos||Distance to first Gene||Genes||Sequence||LeftPos||RightPos||Evidence (Confirmed, Strong, Weak)||References|
|TdcA||activator||tdcAp||nd||-177.0||-205.0||tdcA, tdcB, tdcC, tdcD, tdcE, tdcF, tdcG||
|3267263||3267277||[BCE], [GEA], [SM]|||
|Evolutionary conservation of regulatory elements|