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Synonyms: YeiL |
Summary:
The genes that the YeiL transcriptional activator regulates have not been identified yet, but it has been proposed that this protein might regulate genes involved in post-exponential-phase nitrogen starvation. A gene encoding a potential nucleoside hydrolase and transcribed divergently from yeiL has also been suggested to be subject to YeiL regulation [2]. YeiL, the third member of the CRP/FNR family, has the main structural elements conserved in Crp and Fnr, such as a sensory domain, an α-helix that serves as a dimer interface, and a DNA-recognition helix also found in Fnr. However, the specific residues in the helix for DNA binding are not conserved [2]. The regulatory activity of this protein has been suggested by analogy with FNR; this activity might be modulated by a sensory iron-sulfur cluster or by reversible disulfide-bond formation. Expression of yeiL increases during stationary phase under aerobic conditions and is positively autoregulated [2]. |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | Cyclic nucleotide_binding domain | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | yeiL | ||||||||||||
Genome position: | 2255355-2256014 | ||||||||||||
Length: | 660 bp / 219 aa | ||||||||||||
Operon name: | yeiL | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | yeiL | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
Transcription related (1)
activator (1)
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Regulated operon(s) | yeiL | ||||||
First gene in the operon(s) | yeiL | ||||||
Simple and complex regulons | FNR,IHF,Lrp,YeiL | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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