YiaJ is a transcriptional repressor that negatively controls the expression of genes involved in the catabolism of the rare pentose l-lyxose |CITS:|.
YiaJ is negatively autoregulated, and coordinately represses transcription of the divergent yiaK-S operon, related to degradation of l-lyxose |CITS:|. Additionally, its operon is activated by insertion of IS1 into the yiaJ gene |CITS:|. Although little is known about the mechanism of regulation of the YiaJ regulator, recently it has been demonstrated to act as a repressor by binding to cis-acting elements that overlap yiaKp |CITS:|.
YiaJ shows high homology to the IclR family of regulators; it is composed of two domains, an amino-terminal domain that contains a potential helix-turn-helix DNA-binding motif and a carboxy-terminal region featuring a second motif of unknown function |CITS:|.
|Connectivity class:||Local Regulator|
|Length:||849 bp / 282 aa|
|TU(s) encoding the TF:||
|Regulated gene(s)||lyxK, sgbE, sgbH, sgbU, yiaJ, yiaK, yiaL, yiaM, yiaN, yiaO|
|Multifun term(s) of regulated gene(s)||
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (4)
lyxK, sgbE, sgbU, yiaK
Porters (Uni-, Sym- and Antiporters) (3)
yiaM, yiaN, yiaO
unassigned reversible reactions (1)
Transcription related (1)
yiaJRead more >
|Regulated operon(s)||yiaJ, yiaKLMNO-lyxK-sgbHUE|
|First gene in the operon(s)||yiaJ, yiaK|
|Simple and complex regulons|
|Simple and complex regulatory phrases||
Regulatory phrase (List of promoters regulated by the phrase)
|Functional conformation||Function||Promoter||Sigma factor||Central Rel-Pos||Distance to first Gene||Genes||Sequence||LeftPos||RightPos||Evidence (Confirmed, Strong, Weak)||References|
|YiaJ||repressor||yiaKp||Sigma70||-1.0||-60.0||yiaK, yiaL, yiaM, yiaN, yiaO, lyxK, sgbH, sgbU, sgbE||
|Evolutionary conservation of regulatory elements|