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Synonyms: ZraR-phosphorylated, ZraR |
Summary:
ZraR, "zinc resistance-associated regulator," controls the expression of genes involved in tolerance to high zinc concentrations. Based on chromatin immunoprecipitation followed by sequencing (ChIp-Seq) and RT-qPCR, 25 new genes regulated by ZraR were identified. The genes encode proteins of diverse functions that may be critical to maintain envelope integrity and cell survival under stressful conditions; they are mostly involved in the response against stress [2]. The genes of the ZraR regulon are also involved in replication and protein synthesis [2].The protein ZraR also appears to be involved in palladium ion reduction [3]. This regulator is a member of the two-component regulatory system ZraS/ZraR. The operon contains both genes zraR, which encodes the response regulator, and zraS, which encodes the sensor kinase, and is located next to and in the opposite direction to zraP, a gene regulated by ZraR. It has been suggested that ZraS functions as a zinc receptor [1]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | EBP | ||||||||||||||||||
Sensing class: | External-Two-component systems | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | zraR | ||||||||||||||||||
Genome position: | 4203320-4204645 | ||||||||||||||||||
Length: | 1326 bp / 441 aa | ||||||||||||||||||
Operon name: | zraSR | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | zraP, zraR, zraS | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
fermentation (2)
two component regulatory systems (external signal) (2)
osmotic pressure (1)
pH (1)
protection (1)
Read more >
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Regulated operon(s) | zraP, zraSR | ||||||
First gene in the operon(s) | zraP, zraS | ||||||
Simple and complex regulons | CRP,ZraR ZraR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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ZraR-phosphorylated | activator | zraPp | Sigma54 | -107.0 | -131.0 | zraP |
aagtttcaatGAGTAAAAATGACTCGCtacccgcagc
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4201811 | 4201827 | [GEA], [BPP] | [1] | |
ZraR-phosphorylated | activator | zraPp | Sigma54 | -78.0 | -102.0 | zraP |
cccgcagcagGCGAGTCATTTTTACTCgtttatcatg
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4201782 | 4201798 | [GEA], [APIORCISFBSCS], [BPP] | [1] | |
ZraR-phosphorylated | activator | zraSp | Sigma54 | -115.0 | -136.0 | zraS, zraR |
catgataaacGAGTAAAAATGACTCGCctgctgcggg
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4201782 | 4201798 | [APIORCISFBSCS], [BPP], [GEA], [APIORCISFBSCS], [BPP] | [1] | |
ZraR-phosphorylated | activator | zraSp | Sigma54 | -86.0 | -107.0 | zraS, zraR |
gctgcgggtaGCGAGTCATTTTTACTCattgaaactt
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4201811 | 4201827 | [GEA], [BPP] | [1] |
Functional conformation | Function | Object name | Object type | Distance to first Gene | Sequence | LeftPos | RightPos | Center Position | Growth Condition | Evidence (Confirmed, Strong, Weak) | References | |
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ZraR-phosphorylated | activator | yjjY | Transcription-Unit | -162.5 |
tcatagccttCCGCTTCGAAAATACTTTtcaacgtgtt
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4640231 | 4640249 | 4640239.5 | nd | [IEP], [CSE], [ICWHO] | [2] | |
ZraR-phosphorylated | activator | cspB | Transcription-Unit | -98.5 |
agttctcattTCAGGTGTTATTCACTTAttccttcttt
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1641644 | 1641662 | 1641652.5 | nd | [IEP], [CSE], [ICWHO] | [2] | |
ZraR-phosphorylated | activator | yrdD-rimN-aroE-yrdB | Transcription-Unit | -34.5 |
agtgaatgaaGGTATGCTGCATTAATCAtttctttaat
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3431988 | 3432006 | 3431996.5 | nd | [IEP], [CSE], [ICWHO] | [2] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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