RegulonDB RegulonDB 9.4:Regulon Page

HcaR DNA-binding transcriptional dual regulator

Synonyms: HcaR-HCA, HcaR

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
HcaR     nd nd
HcaR-HCA     nd nd
Evolutionary Family: LysR
Connectivity class: Local Regulator
Gene name: hcaR
  Genome position: 2668006-2668896
  Length: 891 bp / 296 aa
Operon name: hcaR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) hcaB, hcaC, hcaD, hcaE, hcaF, hcaR
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (6)
Transcription related (1)
activator (1)
repressor (1)
operon (1)
Regulated operon(s) hcaEFCBD, hcaR
First gene in the operon(s) hcaE, hcaR
Simple and complex regulons HcaR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  HcaR-HCA activator hcaEp nd -42.0 -92.0 hcaE, hcaF, hcaC, hcaB, hcaD
2668934 2668946 [AIBSCS], [BPP], [GEA] [1], [2], [3]
  HcaR repressor hcaRp nd 25.0 -44.0 hcaR
2668934 2668946 [AIBSCS], [BPP], [GEA] [1], [2], [3]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


 [AIBSCS] Automated inference based on similarity to consensus sequences

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis


 [1] Diaz E., Ferrandez A., Garcia JL., 1998, Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12., J Bacteriol. 180(11):2915-23

 [2] Turlin E., Perrotte-piquemal M., Danchin A., Biville F., 2001, Regulation of the early steps of 3-phenylpropionate catabolism in Escherichia coli., J Mol Microbiol Biotechnol. 3(1):127-33

 [3] Turlin E., Sismeiro O., Le Caer JP., Labas V., Danchin A., Biville F., 2005, 3-phenylpropionate catabolism and the Escherichia coli oxidative stress response., Res Microbiol. 156(3):312-21