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| Synonyms: DhaR-DhaK, DhaR |
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Summary:
"Dihydroxyacetone Regulator," DhaR, is negatively autoregulated and coordinately activates transcription of the divergent dha operon (dhaKLM), which encodes three subunits of the dihydroxyacetone (DHA) kinase [1]. DhaR is inactivated when DnaK binds to the sensing domain of this regulator, in the absence of DHA [1]. Dephosphorylated DhaL (DhaL::ADP) is an antagonist of DhaK and also is able to form complexes with the sensing domain of DhaR. In the presence of DHA, DhaL::ADP displaces DhaK or blocks the association of the DhaK/DhaR complex and DhaR activates the transcription of the dha operon [1]. DhaR belongs to the family of bacterial enhancer-binding proteins which contain three domains: the sensing domain located in the N terminus, the central AAA+ domain, and the C-terminal domain, which contains a helix-turn-helix motif involved in the interaction with DNA. Although the C-terminal domain and the N-terminal domain from DhaR are similar to those of other members of this group, its central domain is not [1]. Read more > |
| Transcription factor |  |
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| TF conformation(s): |
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| Evolutionary Family: | EBP | ||||||||||||||||||
| Connectivity class: | Local Regulator | ||||||||||||||||||
| Gene name: | dhaR | ||||||||||||||||||
| Genome position: | 1251066-1252985 | ||||||||||||||||||
| Length: | 1920 bp / 639 aa | ||||||||||||||||||
| Operon name: | dhaR | ||||||||||||||||||
| TU(s) encoding the TF: |
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| Regulon |
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| Regulated gene(s) | dhaK, dhaL, dhaM, dhaR | ||||||
| Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (3)
Transcription related (1)
activator (1)
repressor (1)
two component regulatory systems (external signal) (1)
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| Regulated operon(s) | dhaKLM, dhaR | ||||||
| First gene in the operon(s) | dhaK, dhaR | ||||||
| Simple and complex regulons | DhaR | ||||||
| Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) | ||||||
| Transcription factor regulation |
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Transcription factor binding sites (TFBSs) arrangements
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| Evolutionary conservation of regulatory elements | |
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| Promoter-target gene evolutionary conservation |
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[BPP] Binding of purified proteins