![]() ![]() |
Synonyms: NsrR-[2Fe-2S]reduced, NsrR-[2Fe-2S]2+ oxidized, NsrR-nitric oxide, NsrR |
Summary:
NsrR, the "nitrite-sensitive repressor" [], regulates genes involved in cell protection against nitric oxide (NO) [1, 6]. A microarray analysis showed that this protein regulates directly or indirectly at least 30 genes, some of which are involved in protection against reactive nitrogen species that can be generated by NO [7]. A ChIP-chip analysis (chromatin immunoprecipitation and microarray analysis) revealed that NsrR regulates, in addition, genes involved in motility and/or biofilm development [5]. NsrR also appears to regulate σE-dependent genes in an RseA-independent manner [9]. NsrR belongs to the Rrf2 family [], which includes among others the [2Fe-2S]-containing transcription factor IscR and the iron regulator RirA [11]. Read more > |
Transcription factor | ![]() ![]() |
||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TF conformation(s): |
|
||||||||||||||||||||||||||||||
Evolutionary Family: | Rrf2 | ||||||||||||||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||||||||||||||
Gene name: | nsrR | ||||||||||||||||||||||||||||||
Genome position: | 4406190-4406615 | ||||||||||||||||||||||||||||||
Length: | 426 bp / 141 aa | ||||||||||||||||||||||||||||||
Operon name: | nsrR-rnr-rlmB-yjfIJ | ||||||||||||||||||||||||||||||
TU(s) encoding the TF: |
|
Transcription factor regulation |
![]() |
---|
Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
NsrR | repressor | aceEp | Sigma70, Sigma38 | -81.0 | -129.0 | aceE, aceF |
aattatccagAAGATGTTGTAAatcaagcgca
|
122883 | 122894 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | bamEp | Sigma24 | 67.0 | -53.0 | bamE |
gtctattatcATCGGCATATTAcagatgagcc
|
2753547 | 2753558 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | bdcAp | Sigma70 | -18.0 | -29.0 | bdcA |
aaacagttttGTAATGCATGTTacataataaa
|
4474077 | 4474088 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | cddp | Sigma70 | 9.0 | -17.0 | cdd |
gttatcccatTACATGATTATGaggcaacgcc
|
2231822 | 2231833 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | dkgBp | Sigma38 | -11.0 | -80.0 | dkgB |
cgcaaaaatcCTCTGCATTTTAcgctcttttt
|
229082 | 229093 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | dkgBp | Sigma38 | 64.0 | -6.0 | dkgB |
tagcattaaaAGAGGCATATTAtggctatccc
|
229156 | 229167 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | dsdCp | Sigma70 | 14.0 | -104.0 | dsdC |
atcaatggagTGATTTACATCTaaaaatgaag
|
2477728 | 2477739 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | feaBp1 | Sigma70 | -184.0 | -211.0 | feaB |
tcgctctgtgAAATGTATTTTTattgttgcat
|
1447303 | 1447314 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5], [6] | |
NsrR | repressor | feaRp2 | Sigma70 | 2.0 | -25.0 | feaR |
atgcaacaatAAAAATACATTTcacagagcga
|
1447303 | 1447314 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | fliAp1 | Sigma70 | -207.0 | -237.0 | fliA, fliZ, tcyJ |
cctacaagttGAATTGCAATTTattgaatttg
|
2002021 | 2002032 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | fliAp1 | Sigma70 | 7.0 | -24.0 | fliA, fliZ, tcyJ |
taatcatgccGATAACTCATATaacgcagggc
|
2001808 | 2001819 | [APIORCISFBSCS], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [5] | |
NsrR | repressor | fliAp2 | Sigma28 | -218.0 | -237.0 | fliA, fliZ, tcyJ |
cctacaagttGAATTGCAATTTattgaatttg
|
2002021 | 2002032 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | fliAp2 | Sigma28 | -5.0 | -24.0 | fliA, fliZ, tcyJ |
taatcatgccGATAACTCATATaacgcagggc
|
2001808 | 2001819 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | grxD | Sigma70 | -13.0 | -74.0 | grxD |
aaagcgtgatGAAAATGTTATTttccgatgcc
|
1734170 | 1734181 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | hcpp | nd | 6.0 | -26.0 | hcp, hcr, poxB |
taaccttaaaCATGTATATTAAATATAACtttaaaaggt
|
913831 | 913849 | [APIORCISFBSCS], [BCE], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [2], [5], [7] | |
NsrR | repressor | hmpp | Sigma38 | -38.0 | -76.0 | hmp |
aaaacaccaaAGAACCATTTACattgcagggc
|
2685754 | 2685765 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | hmpp | Sigma38 | 2.0 | -37.0 | hmp |
tttttataagATGCATTTGAGATACATCAattaagatgc
|
2685789 | 2685807 | [AIBSCS], [CV(GEA)], [GEA] | [1] | |
NsrR | repressor | hmpp | Sigma38 | 20.0 | -19.0 | hmp |
tacatcaattAAGATGCAAAAAaaggaagacc
|
2685811 | 2685822 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | hycAp | Sigma54 | -70.0 | -96.0 | hycA, hycB, hycC, hycD, hycE, hycF, hycG, hycH, hycI |
acacggcgacGAAATTCATCTTtagcttaaaa
|
2850526 | 2850537 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | hypAp | Sigma54 | -96.0 | -116.0 | hypA, hypB, hypC, hypD, hypE, fhlA |
ttttaagctaAAGATGAATTTCgtcgccgtgt
|
2850526 | 2850537 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | lrpp | Sigma70 | 52.0 | -216.0 | lrp |
catgcatgtaAATACCATGTTTaccgtgctag
|
932374 | 932385 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | mepHp | Sigma70 | -61.0 | -139.0 | mepH |
tagctttcacTGCTGCATTTTTttgcgctcgc
|
1734291 | 1734302 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | mhpTp | Sigma32 | -484.0 | -557.0 | mhpT |
actgccgagaACGTGCATTTTGtatgcccatc
|
374897 | 374908 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | ndhp | Sigma70 | 6.0 | -88.0 | ndh |
ctcaatagcgAAGAACATTTTCattgctgtaa
|
1165992 | 1166003 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | norRp | nd | 21.0 | 3.0 | norR |
acagtgaggcAAAGATGAGTTTttccgttgat
|
2832282 | 2832293 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | nrfAp | Sigma70 | -121.0 | -214.0 | nrfA, nrfB, nrfC, nrfD, nrfE, nrfF, nrfG |
ttctttgaggAACATGCAGTTAtgcatgctgt
|
4287545 | 4287556 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5], [7] | |
NsrR | repressor | nrfAp | Sigma70 | -63.0 | -156.0 | nrfA, nrfB, nrfC, nrfD, nrfE, nrfF, nrfG |
taactctaaaGTGGTATTTTACATGCACTtacaattgat
|
4287599 | 4287617 | [APIORCISFBSCS], [BCE], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [5], [8] | |
NsrR | repressor | pgpCp | Sigma32 | 131.0 | 43.0 | pgpC, tadA |
gttttttgacTTAGATGGAACAttgcatcagc
|
2698503 | 2698514 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | rfep | Sigma70 | -1.0 | -117.0 | rfe, wzzE, wecB, wecC, rffG, rffH, rffC, wecE, wzxE, wecF, wzyE, rffM |
catgttatgcAATTTGCATATCaaatggttaa
|
3967794 | 3967805 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | rybBp | Sigma24 | nd | nd | rybB | nd | nd | [GEA] | [9] | ||
NsrR | repressor | sodBp | Sigma70 | -37.0 | -92.0 | sodB |
gcaacagggtAAGTTCATCTTTtgtctcacct
|
1735281 | 1735292 | [AIBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | sufAp | Sigma70 | -68.0 | -100.0 | sufA, sufB, sufC, sufD, sufS, sufE |
aaaagcaggcAAAAAGCATGTTttacggtaaa
|
1764481 | 1764492 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5], [10] | |
NsrR | repressor | sufAp | Sigma70 | -6.0 | -38.0 | sufA, sufB, sufC, sufD, sufS, sufE |
tcattatcacTAACATGCTGTTatacgctgaa
|
1764419 | 1764430 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5], [10] | |
NsrR | repressor | tehAp | nd | -1.0 | -38.0 | tehA, tehB |
aattccataaAATGCATTTCAAATATACTttataaatta
|
1500526 | 1500544 | [AIBSCS], [APIORCISFBSCS], [CV(GEA)], [GEA] | [1], [5] | |
NsrR | repressor | tehAp | nd | 28.0 | -10.0 | tehA, tehB |
taaattaaacAAAATGAGTAAGaagatgcaga
|
1500558 | 1500569 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | thrSp | nd | 80.0 | -84.0 | thrS, infC, rpmI, rplT, pheM, pheS, pheT, ihfA |
catttgttggCTAGATGGTTTCgcaatgaact
|
1802649 | 1802660 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | tsgAp | nd | -64.0 | -113.0 | tsgA |
atcacctcttAAAATGCAATTTagcaaccgat
|
3492450 | 3492461 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | ydbDp | Sigma38 | 39.0 | -40.0 | ydbD |
acaaaagggaAAGATGCATTTCcctttttttc
|
1475099 | 1475110 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | yeaEp | Sigma70 | 5.0 | -84.0 | yeaE |
acaaattctgATAATGCATCTTtccagggcat
|
1865715 | 1865726 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | yeaRp | Sigma70 | -32.0 | -78.0 | yeaR, yoaG |
taaccaataaATGGTATTTAAAATGCAAAttatcaggcg
|
1880017 | 1880035 | [AIBSCS], [CV(GEA)], [GEA] | [4] | |
NsrR | repressor | ygbAp | nd | -118.0 | -140.0 | ygbA |
tggttccgggAAAGATGCTGTTttgcagcttt
|
2856941 | 2856952 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | ygbAp | nd | -7.0 | -29.0 | ygbA |
ttaagattaaGATGTAATATAAATACATCttaatgaggt
|
2856826 | 2856844 | [AIBSCS], [APIORCISFBSCS], [CV(GEA)], [GEA] | [1], [5] | |
NsrR | repressor | ygbAp | nd | -1.0 | -23.0 | ygbA |
agatgtaataTAAATACATCTTaatgaggtgg
|
2856824 | 2856835 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | yibDp1 | Sigma70 | -115.0 | -183.0 | waaH |
ataatctgttAAATATGTAAAAtcctgtcagt
|
3790259 | 3790270 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [5] | |
NsrR | repressor | ytfEp | nd | -12.0 | -38.0 | ytfE |
ttgccttaaaGATGCATTTAAAATACATCttatcttatt
|
4432012 | 4432030 | [AIBSCS], [APIORCISFBSCS], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1], [5], [7] |
Alignment and PSSM for NsrR TFBSs | ![]() |
---|
Aligned TFBS of NsrR |
---|
Sequence | |
---|---|
TAAGATGCATTTGAG | |
AAAGATGCATTTAAA | |
AAAGATGCATTTCCC | |
TAAAATGCATTTCAA | |
TAAAATGCAATTTAG | |
AAAGATGCATTATCA | |
TAACATGCATTACAA | |
AAAGATGCTGTTTTG | |
AAACATGCTTTTTGC | |
TAAGATGTATTTATA | |
TAAAATGCAAATTAT | |
AAACATGTATATTAA | |
GAACATGCAGTTATG | |
TAAGATGCAAAAAAA | |
TAACATGCTGTTATA | |
AAAGATGAATTTCGT | |
AAACATGGTATTTAC | |
AAAGATGAGTTTTTC | |
AAAGATGAACTTACC | |
TTAGATGTAAATCAC | |
TAAATTGCAATTCAA | |
AAAGAGGCATATTAT | |
TTACATGCACTTACA | |
AAAAATACATTTCAC | |
GAAAATGTTATTTTC | |
AAAAATGCAGCAGTG | |
TTACATGATTATGAG | |
GAAGATGTTGTAAAT | |
TAAAATGCAGAGGAT | |
GAACGTGCATTTTGT | |
AAATATGTAAAATCC | |
GAAAATGTTCTTCGC | |
CAATTTGCATATCAA | |
TAATATGCCGATGAT | |
TTAGATGGAACATTG | |
CAAAATGAGTAAGAA | |
GTAAATGGTTCTTTG | |
TTATATGAGTTATCG | |
CTAGATGGTTTCGCA |
Position weight matrix (PWM). NsrR matrix-quality result |
---|
A 14 32 39 11 36 0 1 6 25 9 11 9 8 19 13 C 3 0 0 9 0 0 0 22 1 3 3 1 9 7 10 G 6 0 0 15 1 1 38 4 3 7 0 1 7 4 9 T 16 7 0 4 2 38 0 7 10 20 25 28 15 9 7 |
Consensus |
---|
; consensus.strict tAAgATGcattttac ; consensus.strict.rc GTAAAATGCATCTTA ; consensus.IUPAC wAAsATGcatttyav ; consensus.IUPAC.rc BTRAAATGCATSTTW ; consensus.regexp [at]AA[cg]ATGcattt[ct]a[acg] ; consensus.regexp.rc [CGT]T[AG]AAATGCAT[CG]TT[AT] |
Evolutionary conservation of regulatory elements | ![]() |
---|
Reference(s) |
![]() |
---|---|