![]() ![]() |
Synonyms: PepA |
Summary:
Aminopeptidase A/I is a Peptidase that binds DNA and controls the transcription of the operon involved in the synthesis of carbamoyl phosphate, which is an intermediate related to the pyrimidine nucleotide pathway [1, 2, 3]. This protein also is required for maintenance of plasmid monomers, which is critical for proper plasmid segregation [4]. Aminopeptidase A/I is a part of the site-specific recombination system required to decatenate the plasmids ColE1 and pSC101, maintaining them as monomers []. Aminopeptidase A/I is responsible for coordinating DNA strands during recombination, pairing cer sites in ColE1 plasmids and allowing the formation of Holliday junctions []. Aminopeptidase A/I, along with ArgR, may be involved in blocking trans-recombination, thus preventing the formation of new catenated plasmids during recombination []. Read more > |
Transcription factor | ![]() ![]() |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TF conformation(s): |
|
||||||||||||
Evolutionary Family: | Aminopeptidase | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | pepA | ||||||||||||
Genome position: | 4484440-4485951 | ||||||||||||
Length: | 1512 bp / 503 aa | ||||||||||||
Operon name: | pepA | ||||||||||||
TU(s) encoding the TF: |
|
Regulon |
![]() ![]() |
||||||
---|---|---|---|---|---|---|---|
Regulated gene(s) | carA, carB, pepA | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
arginine (2)
pyrimidine biosynthesis (2)
proteins/peptides/glycopeptides (1)
DNA recombination (1)
Transcription related (1)
|
||||||
Regulated operon(s) | carAB, pepA | ||||||
First gene in the operon(s) | carA, pepA | ||||||
Simple and complex regulons | Fis,IHF,PepA,PurR,RutR PepA | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
![]() |
---|
Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
PepA | repressor | carAp1 | Sigma70 | -173.0 | -273.0 | carA, carB |
aattttgaccATTTGGTCCACTTTTTTCTGCTCGTTTttatttcatg
|
29365 | 29391 | [BPP], [CV(GEA)], [CV(GEA)], [GEA], [IMP] | [1], [2], [3] | |
PepA | repressor | carAp1 | Sigma70 | -79.0 | -179.0 | carA, carB |
ttttgtcgctTAATGCCTGTAAAACATGCATGAGCCAcaaaataata
|
29459 | 29485 | [BPP], [GEA] | [1], [2], [3] | |
PepA | repressor | pepAp1 | Sigma70 | -43.0 | -231.0 | pepA |
cgtaaaaactCGTCTTTTGCAGGATTTTAGCTTGTTTcatggcttaa
|
4486169 | 4486195 | [BPP] | [2] |
Evolutionary conservation of regulatory elements | ![]() |
---|
Reference(s) |
![]() |
---|---|