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Synonyms: AscG |
Summary:
The AscG, "Arbutin-salicin-cellibiose," transcriptional regulator represses the expression of a cryptic operon (ascFB) whose genes are involved in transport and utilization of the β-glucoside sugars arbutin, salicin, and cellibiose. This operon is activated only when the repressor is inactivated through the interruption of the gene by an insertion sequence [1] AscG also regulates prpBC for propionate catabolism [2] AscG is a GalR-type transcription factor and has a helix-turn-helix motif [1, 2] AscG recognizes and binds the consensus palindromic sequence TGAAACCGGTTTCA [2] The ascG gene is transcribed divergently from the operon it regulates [1] ascG is paralogous to galR [2] A high level of AscG is always present in wild-type Escherichia coli cells [2] Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | GalR/LacI | ||||||||||||
Sensing class: | External sensing using transported metabolites | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | ascG | ||||||||||||
Genome position: | 2838254-2839264 | ||||||||||||
Length: | 1011 bp / 336 aa | ||||||||||||
Operon name: | ascG | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | ascB, ascF, htpG, prpR, ybiT | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (2)
Phosphotransferase Systems (PEP-dependent PTS) (1)
membrane (1)
chaperoning, repair (refolding) (1)
fatty acids (1)
Read more >
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Regulated operon(s) | ascFB, htpG, prpR, ybiT | ||||||
First gene in the operon(s) | ascF, htpG, prpR, ybiT | ||||||
Simple and complex regulons | AscG AscG,CRP AscG,CRP,PhoB,PrpR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence![]() |
LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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AscG | repressor | ascFp | Sigma70 | -72.5 | -167.5 | ascF, ascB |
aaaatattcaGGTGACCGGTTTCACaaatataaaa
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2839350 | 2839364 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [1], [2] | |
AscG | repressor | ascFp | Sigma70 | 4.5 | -91.5 | ascF, ascB |
catgattttgTGAAACCGGTTTCTTaattccgttt
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2839426 | 2839440 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2] | |
AscG | repressor | htpGp1 | Sigma32 | 89.5 | 44.5 | htpG |
cagtcagaagTGAAACAGCTTCTGCacctgatgat
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495157 | 495171 | [AIBSCS], [BPP] | [2] | |
AscG | repressor | prpRp | Sigma70 | -58.5 | -86.5 | prpR |
tttcagttaaCGTTTCAggcaatgttt
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348527 | 348533 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2] | |
AscG | repressor | prpRp | Sigma70 | -46.5 | -74.5 | prpR |
tttcaggcaaTGTTTCAccgcgtttca
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348515 | 348521 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2] | |
AscG | repressor | prpRp | Sigma70 | -36.5 | -64.5 | prpR |
tgtttcaccgCGTTTCAttgcaacaat
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348505 | 348511 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2] | |
AscG | repressor | prpRp | Sigma70 | -29.5 | -57.5 | prpR |
ccgcgtttcaTTGCAACaattatgaaa
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348498 | 348504 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2] | |
AscG | repressor | prpRp | Sigma70 | -18.5 | -46.5 | prpR |
tgcaacaattATGAAACaagactaaac
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348487 | 348493 | [AIBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2] | |
AscG | repressor | ybiTp | nd | -108.5 | -124.5 | ybiT |
cagctcacagTGAAATCAGATGTGTacgaaatcac
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855832 | 855846 | [AIBSCS], [BPP] | [2] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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