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Synonyms: FeaR |
Summary:
"Phenylethylamine regulator," FeaR, is considered an activator of phenylacetate synthesis from 2-phenylethylamine (PEA). This regulator is regulated by catabolic repression, and highly expressed in the presence of succinate [3]. FeaR controls expression of a pathway for the degradation of potentially toxic aromatic compounds [2]. It is induced by tyramine, and in the absence of glucose, it activates the expression of amine oxidase and phenylacetaldehyde dehydrogenase, proteins involved in 2-phenylethylamine catabolism [1, 2, 4]. Although it has not been possible to test the ligand binding to FeaR, these data and those of others suggest that it is a substrate or intermediate of the TynA/FeaB pathway, as it is more likely that an aldehyde (tyramine) is the direct inducer for the PEA catabolic pathway and a likely coeffector of FeaR [2]. FeaR belongs to the AraC/XylS family of transcriptional regulators [1, 3]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | AraC/XylS | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | feaR | ||||||||||||
Genome position: | 1446378-1447283 | ||||||||||||
Length: | 906 bp / 301 aa | ||||||||||||
Operon name: | feaR | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | feaB, tynA | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
amines (2)
nicotinamide adenine dinucleotide (1)
amino acids (1)
threonine catabolism (1)
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Regulated operon(s) | feaB, tynA | ||||||
First gene in the operon(s) | feaB, tynA | ||||||
Simple and complex regulons | CRP,FeaR,NsrR FeaR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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FeaR | activator | feaBp1 | Sigma70 | -64.0 | -91.0 | feaB |
cgatttgcggAGCTTGTCACAGCTGACAAAGcgaatgtcac
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1447418 | 1447438 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [1], [2] | |
FeaR | activator | feaBp1 | Sigma70 | -43.0 | -70.0 | feaB |
gctgacaaagCGAATGTCACAGCGAAAAAAGtgacttttct
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1447439 | 1447459 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [2] | |
FeaR | activator | tynAp | Sigma70 | 26.0 | -124.0 | tynA |
cactgtatgaAAAGCTGGCACACCTGCCAAACaacctggcag
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1451463 | 1451484 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [2] | |
FeaR | activator | tynAp | Sigma70 | 47.0 | -103.0 | tynA |
cctgccaaacAACCTGGCAGGTGCAGGCAATcccctttgca
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1451442 | 1451462 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [2] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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