RegulonDB RegulonDB 9.4:Regulon Page

AlaS DNA-binding transcriptional repressor

Synonyms: AlaS-L-alanine, AlaS

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
AlaS Non-Functional   Apo [BPP] [1]
AlaS-L-alanine Functional Allosteric Holo [BPP] [1]
Evolutionary Family: Class II aminoacyl_tRNA synthetase
Connectivity class: Local Regulator
Gene name: alaS
  Genome position: 2819381-2822011
  Length: 2631 bp / 876 aa
Operon name: alaS
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) alaS
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
amino acid -activation (1)
repressor (1)
Regulated operon(s) alaS
First gene in the operon(s) alaS
Simple and complex regulons AlaS
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  AlaS-L-alanine repressor alaSp nd -6.5 -85.5 alaS
2822080 2822113 [BPP], [GEA] [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis


 [1] Putney SD., Schimmel P., 1981, An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription., Nature. 291(5817):632-5