EnvR, also known as AcrS, represses the transcription of genes encoding a drug efflux pump that has a role in resistance to antibiotics |CITS:|.
This protein is homologous to some other proteins, such as MtrR of Neisseria gonorrhoeae, TcmR of Streptomyces glaucescens, JadR2 from Streptomyces venezuelae, and AcrR from Escherichia coli |CITS:|. All of these proteins, including EnvR, have a helix-turn-helix motif close to the N terminus |CITS:[ 7592375]|.
EnvR recognizes and binds a 24-bp palindromic DNA sequence |CITS:|. The same sequence is also recognized by the transcriptional repressor AcrR |CITS:|.
envR is adjacent and divergent in the genome to acrEF, an operon that encodes another drug efflux pump; however, it is not regulated or is only lightly affected by EnvR |CITS:|. Both of these transcription units appears to be repressed by HNS |CITS:|.
|Connectivity class:||Local Regulator|
|Length:||663 bp / 220 aa|
|TU(s) encoding the TF:||
|Regulated gene(s)||acrA, acrB|
|Multifun term(s) of regulated gene(s)||
MultiFun Term (List of genes associated to the multifun term)
Porters (Uni-, Sym- and Antiporters) (2)
drug resistance/sensitivity (2)
|First gene in the operon(s)||acrA|
|Simple and complex regulons|
|Simple and complex regulatory phrases||
Regulatory phrase (List of promoters regulated by the phrase)
|Functional conformation||Function||Promoter||Sigma factor||Central Rel-Pos||Distance to first Gene||Genes||Sequence||LeftPos||RightPos||Evidence (Confirmed, Strong, Weak)||References|
|485709||485732||[AIBSCS], [BPP], [GEA]||, |
|Evolutionary conservation of regulatory elements|
 Hirakawa H., Takumi-Kobayashi A., Theisen U., Hirata T., Nishino K., Yamaguchi A., 2008, AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli., J Bacteriol. 190(18):6276-9
 Rodionov DA., Gelfand MS., Mironov AA., Rakhmaninova AB., 2001, Comparative approach to analysis of regulation in complete genomes: multidrug resistance systems in gamma-proteobacteria., J Mol Microbiol Biotechnol. 3(2):319-24