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Synonyms: MurR-N-acetyl-D-muramate 6-phosphate, MurR |
Summary:
MurR "N-acetyl muramic acid repressor," represses genes involved in the catabolism of cell wall sugars [1] It represses transcription from the murQ promoter and also interferes with its own transcription. murR and murQ are unique and now well-known genes that are regulated by MurR. They are divergently orientated and expressed from nonoverlapping face-to-face (convergent) promoters, and their transcripts are complementary at their 5' ends [1] MurR is a member of the RpiR/AlsR family of transcriptional regulators, whose members contain two domains, a highly conserved N-terminal HTH domain and a C-terminal SIS (sugar phosphate isomerase/sugar phosphate-binding) domain [1, 3] It forms a stable multimer (most likely a tetramer) and binds to two adjacent inverted repeats within the murR/murQ operator region, preventing recruitment of RNA polymerase. MurNAc-6-P is the effector of MurR. MurR carries a so-called SIS domain in its C terminal which is involved in MurNAc-6-P binding. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | RpiR | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | murR | ||||||||||||||||||
Genome position: | 2544752-2545609 | ||||||||||||||||||
Length: | 858 bp / 285 aa | ||||||||||||||||||
Operon name: | murR | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | murP, murQ, murR | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (1)
Phosphotransferase Systems (PEP-dependent PTS) (1)
murein turnover, recycling (1)
Transcription related (1)
transcriptional level (1)
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Regulated operon(s) | murQP-yfeW, murR | ||||||
First gene in the operon(s) | murQ, murR | ||||||
Simple and complex regulons | CRP,MurR MurR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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MurR | repressor | murQp | Sigma38 | -44.0 | -84.0 | murQ, murP |
ctgcgagtgtAGACTCAATGATTCCTttaagcctgt
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2545682 | 2545697 | [GEA], [BPP], [ICWHO] | [1] | |
MurR | repressor | murQp | Sigma38 | -12.0 | -52.0 | murQ, murP |
ctgtcaattcGGGATATATGATTCCAtacatctgca
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2545714 | 2545729 | [GEA], [BPP], [ICWHO] | [1] | |
MurR | repressor | murQp1 | Sigma70 | -44.0 | -84.0 | murQ, murP |
ctgcgagtgtAGACTCAATGATTCCTttaagcctgt
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2545682 | 2545697 | [GEA], [BPP], [ICWHO] | [1] | |
MurR | repressor | murQp1 | Sigma70 | -12.0 | -52.0 | murQ, murP |
ctgtcaattcGGGATATATGATTCCAtacatctgca
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2545714 | 2545729 | [GEA], [BPP], [ICWHO] | [1] | |
MurR | repressor | murQp2 | Sigma70 | -52.0 | -84.0 | murQ, murP |
ctgcgagtgtAGACTCAATGATTCCTttaagcctgt
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2545682 | 2545697 | [BPP], [GEA], [ICWHO], [BPP], [ICWHO] | [1] | |
MurR | repressor | murQp2 | Sigma70 | -20.0 | -52.0 | murQ, murP |
ctgtcaattcGGGATATATGATTCCAtacatctgca
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2545714 | 2545729 | [BPP], [GEA], [BPP], [ICWHO] | [1] | |
MurR | activator | murRp | Sigma70 | -125.0 | -309.0 | murR |
taacatcgatCGCCGCGGCGATATCcggcagtacg
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2545911 | 2545925 | [GEA], [APIORCISFBSCS] | [2] | |
MurR | repressor | murRp | Sigma70 | -125.0 | -309.0 | murR |
taacatcgatCGCCGCGGCGATATCcggcagtacg
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2545911 | 2545925 | [GEA], [APIORCISFBSCS] | [2] | |
MurR | activator | murRp2 | Sigma38 | -125.0 | -309.0 | murR |
taacatcgatCGCCGCGGCGATATCcggcagtacg
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2545911 | 2545925 | [GEA], [APIORCISFBSCS] | [2] | |
MurR | repressor | murRp2 | Sigma38 | -125.0 | -309.0 | murR |
taacatcgatCGCCGCGGCGATATCcggcagtacg
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2545911 | 2545925 | [GEA], [APIORCISFBSCS] | [2] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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