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Synonyms: BluR |
Summary:
BluR is a MerR-like regulator that contains an N-terminal helix-turn-helix DNA-binding region and a ligand-binding region in the C-terminal domain []. BluR functions as a repressor for genes involved in the modulation of biofilm formation and for acid resistance genes [2]. Its expression is strongly induced at low temperatures [2, 4]. BluR is a paralogue of MlrA, and it represses the transcription of the ycgZ-ymgA-ariR-ymgC operon [2, 3]. This operon is transcribed divergently on the opposite strand, under the control of σ38 (RpoS) RNA polymerase [2, 5]. Its gene products are involved in the production of colanic acid, a component of the biofilm matrix, via the Rcs phosphorelay system [6, 7, 8, 9]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | MerR | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | bluR | ||||||||||||
Genome position: | 1213328-1214059 | ||||||||||||
Length: | 732 bp / 243 aa | ||||||||||||
Operon name: | bluR | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | ariR, ycgZ, ymgA, ymgC | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
unknown (1)
pH (1)
other (mechanical, nutritional, oxidative stress) (1)
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Regulated operon(s) | ycgZ-ymgA-ariR-ymgC | ||||||
First gene in the operon(s) | ycgZ | ||||||
Simple and complex regulons | BluR,MarA | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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BluR | repressor | ycgZp | Sigma38, Sigma70 | -29.5 | -66.5 | ycgZ, ymgA, ariR, ymgC |
atttatcattCTGTACACATATTTCGTACAAgtttgctatt
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1215713 | 1215733 | [BPP], [CV(SM)], [GEA], [SM] | [2], [3] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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