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GlrR DNA-binding transcriptional activator

Synonyms: GlrR-Pasp56, GlrR


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
GlrR Non-Functional   Apo [BPP], [GEA], [IDA], [IEP] [1]
GlrR-Pasp56 Functional Covalent Holo [BPP], [GEA], [IDA], [IEP] [1]
Evolutionary Family: EBP
Connectivity class: Local Regulator
Gene name: glrR
  Genome position: 2687469-2688803
  Length: 1335 bp / 444 aa
Operon name: glrR-glnB
TU(s) encoding the TF:
Transcription unit        Promoter
glrR
null
glrR-glnB
null


Regulon       
Regulated gene(s) glmY, rpoE, rseA, rseB, rseC
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
Transcription related (4)
sigma factors, anti-sigmafactors (4)
other (mechanical, nutritional, oxidative stress) (4)
temperature extremes (2)
starvation (2)
Read more >
Regulated operon(s) glmY, rpoE-rseABC
First gene in the operon(s) glmY, rpoE
Simple and complex regulons GlrR,IHF
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[GlrR,+](2)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  GlrR-Pasp56 activator glmYp1 Sigma54 -221.5 -221.5 glmY
agcttttttgTGTCTGTAAATCACGACAatgggtggtt
2691553 2691570 [BPP], [GEA], [HIBSCS], [SM] [1]
  GlrR-Pasp56 activator glmYp1 Sigma54 -188.5 -188.5 glmY
tggtttgccgTGTCGCTTTCTGGCGACActtaactcat
2691520 2691537 [BPP], [GEA], [HIBSCS], [SM] [1]
  GlrR-Pasp56 activator glmYp1 Sigma54 -125.5 -125.5 glmY
tatcttaagtTGTCTCTTTTTAGCGACAcagtggctga
2691457 2691474 [BPP], [GEA], [HIBSCS], [SM] [1]
  GlrR-Pasp56 activator rpoEp2b Sigma70 -90.5 -417.5 rpoE, rseA, rseB, rseC
gtcacatgaaTGTTCAGGGAGAGTATTCATtttctttgtt
2710420 2710439 [BPP], [GEA], [HIBSCS] [2]
  GlrR-Pasp56 activator rpoEp2b Sigma70 -65.5 -392.5 rpoE, rseA, rseB, rseC
tcattttcttTGTTTAATTTACTAAACAtggtttggtc
2710396 2710413 [BPP], [GEA], [HIBSCS] [2]
  GlrR-Pasp56 activator rpoEp2b Sigma70 -26.5 -353.5 rpoE, rseA, rseB, rseC
gcatagcatcATGTTGTGCGGATAAACAcctgctattt
2710357 2710374 [BPP], [GEA], [HIBSCS] [2]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [IDA] Inferred from direct assay

 [IEP] Inferred from expression pattern

 [HIBSCS] Human inference based on similarity to consensus sequences

 [SM] Site mutation



Reference(s)    

 [1] Reichenbach B., Gopel Y., Gorke B., 2009, Dual control by perfectly overlapping sigma(54)- and sigma(70)-promoters adjusts small RNA GlmY expression to different environmental signals., Mol Microbiol. 74(5):1054-70

 [2] Klein G., Stupak A., Biernacka D., Wojtkiewicz P., Lindner B., Raina S., 2016, Multiple transcriptional factors regulate transcription of the rpoE gene in Escherichia coli under different growth conditions and when the lipopolysaccharide biosynthesis is defective., J Biol Chem



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