YoeB and YefM are a toxin-antitoxin pair .
YefM has similarity to the Axe protein of the Txe-Axe toxin-antitoxin pair, which is encoded by a multidrug resistance
episome isolated from Enterococcus faecium .
The YefM protein appears to lack secondary structure, and its native conformation is proposed to be unfolded. A
linear recognition element which can be recognized by YoeB was identified using peptide array technology .
Regulation has been described . Transcription is induced upon biofilm formation .
|Connectivity class:||Local Regulator|
|Length:||252 bp / 83 aa|
|TU(s) encoding the TF:||
|Regulated gene(s)||yefM, yoeB|
|Multifun term(s) of regulated gene(s)||
|First gene in the operon(s)||yefM|
|Simple and complex regulons|
|Simple and complex regulatory phrases||
Regulatory phrase (List of promoters regulated by the phrase)
|Functional conformation||Function||Promoter||Sigma factor||Central Rel-Pos||Distance to first Gene||Genes||Sequence||LeftPos||RightPos||Evidence (Confirmed, Strong, Weak)||References|
|2089737||2089750||[BPP], [GEA], [HIBSCS]|||
|2089725||2089738||[BPP], [GEA], [HIBSCS]|||
|Evolutionary conservation of regulatory elements|
 Kedzierska B., Lian LY., Hayes F., 2007, Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression., Nucleic Acids Res. 35(1):325-39