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Summary:
The DksA protein binds directly to RNA polymerase, affecting transcript elongation and potentiating allosterically the effect of the alarmone ppGpp on transcription initiation Perederina A, Svetlov V, Vassylyeva MN, Tahirov TH, Yokoyama S, Artsimovitch I, Vassylyev DG,2004. Molodtsov V, Sineva E, Zhang L, Huang X, Cashel M, Ades SE, Murakami KS,2018. DksA binding to the RNA polymerase (RNAP) secondary channel interferes with the proper ribonucleotide positioning in the RNAP active site, decreasing open complex stability but only at promoters with intrinsically unstable open complexes, such as the ribosomal promoters Doniselli N, Rodriguez-Aliaga P, Amidani D, Bardales JA, Bustamante C, Guerra DG, Rivetti C,2015 DksA together with ppGpp is required for regulation of transcription of ribosomal RNA promoters Paul BJ,2004. DksA and ppGpp independently reduce transcription of the rrsBp1 promoter. The additions of both ppGpp and DksA have independent cumulative effects on transcription inhibition of the rrsBp1 promoter Doniselli N, Rodriguez-Aliaga P, Amidani D, Bardales JA, Bustamante C, Guerra DG, Rivetti C,2015 DksA is involved in translational regulation of RpoS Brown L,2002. dksA mutants have pleiotropic phenotypes. A null mutant is viable Kang PJ,1990. Read more > |
Transcription factor | ![]() ![]() |
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Gene name: | dksA | ||||||||||
Genome position: | 160149-160604 | ||||||||||
Length: | 456 bp / 151 aa | ||||||||||
Operon name: | sfsA-dksA-gluQ | ||||||||||
TU(s) encoding the TF: |
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Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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DksA | activation | argXp | Sigma70 | nd | nd | argX, hisR, leuT, proM | nd | nd | [IDA] | [1] | ||
DksA | inhibition | dksAp2 | Sigma70 | nd | nd | dksA, gluQ | nd | nd | [APPH], [GEA], [IMP] | [2], [3] | ||
DksA | activation | fimBp2 | nd | nd | nd | fimB | nd | nd | [APPH], [GEA] | [4] | ||
DksA | activation | flup | Sigma70 | nd | nd | isrC, flu | nd | nd | [GEA] | [5] | ||
DksA | inhibition | idlPp | Sigma38 | nd | nd | idlP, iraD | nd | nd | [GEA], [IMP] | [6] | ||
DksA | inhibition | iraDp1 | Sigma70 | nd | nd | ytiC, ytiD, idlP, iraD | nd | nd | [GEA], [IMP] | [6] | ||
DksA | activation | rpoEp | Sigma24 | nd | nd | rpoE, rseA, rseB, rseC | nd | nd | [GEA] | [7] | ||
DksA | activation | rpoEp2a | Sigma70 | nd | nd | rpoE, rseA, rseB, rseC | nd | nd | [GEA] | [7] | ||
DksA | inhibition | rrsAp | Sigma32 | nd | nd | rrsA, ileT, alaT, rrlA, rrfA | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsAp1 | Sigma70 | nd | nd | rrsA, ileT, alaT, rrlA, rrfA | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsBp | Sigma32 | nd | nd | rrsB, gltT, rrlB, rrfB | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsBp1 | Sigma70 | nd | nd | rrsB, gltT, rrlB, rrfB | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsCp | Sigma32 | nd | nd | rrsC, gltU, rrlC, rrfC | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsCp1 | Sigma70 | nd | nd | rrsC, gltU, rrlC, rrfC | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsDp | Sigma32 | nd | nd | rrsD, ileU, alaU, rrlD, rrfD, thrV, rrfF | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsDp1 | Sigma70 | nd | nd | rrsD, ileU, alaU, rrlD, rrfD, thrV, rrfF | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsEp1 | Sigma70 | nd | nd | rrsE, gltV, rrlE, rrfE | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsEp3 | Sigma32 | nd | nd | rrsE, gltV, rrlE, rrfE | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsGp | Sigma32 | nd | nd | rrsG, gltW, rrlG, rrfG | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsGp1 | Sigma70 | nd | nd | rrsG, gltW, rrlG, rrfG | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsHp | Sigma32 | nd | nd | rrsH, ileV, alaV, rrlH, rrfH | nd | nd | [APPH], [GEA] | [8] | ||
DksA | inhibition | rrsHp1 | Sigma70 | nd | nd | rrsH, ileV, alaV, rrlH, rrfH | nd | nd | [APPH], [GEA] | [8] | ||
DksA | activation | rseAp3 | Sigma24 | nd | nd | rseA, rseB, rseC | nd | nd | [BPP], [IEP] | [9] | ||
DksA | activation | rybBp | Sigma24 | nd | nd | rybB | nd | nd | [BPP], [IEP] | [9] | ||
DksA | activation | sgrRp | Sigma70 | nd | nd | sgrR, sroA, thiB, thiP, thiQ | nd | nd | [GEA] | [10] | ||
DksA | activation | sgrSp2 | Sigma38 | nd | nd | sgrS, sgrT, setA | nd | nd | [GEA] | [10] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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