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RelB-RelE DNA-binding transcriptional repressor

Synonyms: RelB-RelE


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
RelB-RelE     nd nd
Evolutionary Family: RelB, RelE
Connectivity class: Local Regulator
Gene name: relB
  Genome position: 1645633-1645872
  Length: 240 bp / 79 aa
Operon name: relBE-hokD
TU(s) encoding the TF:
Transcription unit        Promoter
relBE
null
relBE-hokD
relBp
Gene name: relE
  Genome position: 1645346-1645633
  Length: 288 bp / 95 aa
Operon name: relBE-hokD
TU(s) encoding the TF:
Transcription unit        Promoter
relBE
null
relBE-hokD
relBp


Regulon       
Regulated gene(s) hokD, relB, relE
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
RNA degradation (2)
translation attenuation and efficiency (2)
cell killing (2)
prophage genes and phage related functions (1)
Transcription related (1)
Read more >
Regulated operon(s) relBE-hokD
First gene in the operon(s) relB
Simple and complex regulons RelB,RelB-RelE
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  RelB-RelE repressor relBp Sigma70 -13.5 -44.5 relB, relE, hokD
cctaagcatgTTGTAGTGCGATacttgtaatg
1645911 1645922 [BPP], [GEA], [HIBSCS] [1]
  RelB-RelE repressor relBp Sigma70 1.5 -30.5 relB, relE, hokD
agtgcgatacTTGTAATGACATttgtaattac
1645897 1645908 [BPP], [HIBSCS] [1]
  RelB-RelE repressor relBp Sigma70 13.5 -18.5 relB, relE, hokD
gtaatgacatTTGTAATTACAAgaggtgtaag
1645885 1645896 [BPP], [HIBSCS] [1]
  RelB-RelE repressor relBp Sigma70 28.0 -4.0 relB, relE, hokD
attacaagagGTGTAAGACATgggtagcatt
1645871 1645881 [BPP], [GEA], [HIBSCS] [1]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [HIBSCS] Human inference based on similarity to consensus sequences



Reference(s)    

 [1] Li GY., Zhang Y., Inouye M., Ikura M., 2008, Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module., J Mol Biol. 380(1):107-19



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