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Synonyms: ComR-Cu+, ComR |
Summary:
ComR is a member of the TetR family of transcriptional repressors and has been implicated in the the response of E. coli K-12 to copper. In in vitro experiments, ComR binds to a 60 bp promotor region upstream of the comC gene [1] but is released in the presence of copper, silver or gold. Expression of comC is dramatically increased (approx 270 fold) in a comR negative strain upon exposure to 3mM copper. comR knockout mutants have lower cytoplasmic copper levels compared to the wild type when exposed to copper [1]. Expression of comR is not affected by copper [1]. Genome-wide ComR binding sites were determined in vivo in M9 glucose minimal medium by chromatin immunoprecipitation assays (ChIP-exo) 34428301]|. Review: [2]. |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | TetR/AcrR | |||||||||||||||||||||
TFBs length: | 19 | |||||||||||||||||||||
TFBs symmetry: | inverted-repeat | |||||||||||||||||||||
Connectivity class: | Local Regulator | |||||||||||||||||||||
Gene name: | comR | |||||||||||||||||||||
Genome position: | 1168200-1168832 | |||||||||||||||||||||
Length: | 633 bp / 210 aa | |||||||||||||||||||||
Operon name: | comR | |||||||||||||||||||||
TU(s) encoding the TF: |
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Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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ComR | repressor | bhsAp | Sigma24 | nd | nd | bhsA | nd | nd | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS] | S | [1], [1] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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