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Synonyms: ComR, ComR-Cu+ |
Summary:
ComR is a member of the TetR family of transcriptional repressors and has been implicated in the the response of E. coli K-12 to copper. In in vitro experiments, ComR binds to a 60 bp promotor region upstream of the comC gene [1] but is released in the presence of copper, silver or gold. Expression of comC is dramatically increased (approx 270 fold) in a comR negative strain upon exposure to 3mM copper. comR knockout mutants have lower cytoplasmic copper levels compared to the wild type when exposed to copper [1]. Expression of comR is not affected by copper [1]. Review: []. |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | TetR/AcrR | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | comR | ||||||||||||||||||
Genome position: | 1168200-1168832 | ||||||||||||||||||
Length: | 633 bp / 210 aa | ||||||||||||||||||
Operon name: | comR | ||||||||||||||||||
TU(s) encoding the TF: |
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Transcription factor regulation |
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