RegulonDB RegulonDB 11.0:Regulon Page

HypT DNA-binding transcriptional dual regulator

Synonyms: HypT-Met-oxidized
Based on microarray analysis it was shown that QseD, Quorum-sensing Escherichia coli regulator D, downregulates the flagellum regulon, decreasing motility [3]

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
HypT-Met-oxidized Functional   nd nd
Evolutionary Family: LysR
Connectivity class: Local Regulator
Gene name: hypT
  Genome position: 4557378-4558289
  Length: 912 bp / 303 aa
Operon name: hypT
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) cydA, cydB, cysH, fecA, fecB, fecC, fecD, fecE, metB, metI, metL, metN, metQ
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (5)
Fe aquisition (4)
ABC superfamily, membrane component (3)
electron acceptors (2)
ABC superfamily, periplasmic binding component (2)
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Regulated operon(s) cydAB, cysJIH, fecABCDE, metBL, metNIQ
First gene in the operon(s) cydA, cysH, fecA, metB, metN
Simple and complex regulons ArcA,FNR,H-NS,HypT
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  HypT-Met-oxidized activator cydAp1 Sigma70 nd nd cydA, cydB nd nd [GEA], [BPP] [1]
  HypT-Met-oxidized activator cysHp nd nd nd cysH nd nd [GEA], [BPP] [1], [2]
  HypT-Met-oxidized repressor fecAp nd nd nd fecA, fecB, fecC, fecD, fecE nd nd [GEA], [BPP] [1], [2]
  HypT-Met-oxidized activator metBp Sigma70 nd nd metB, metL nd nd [GEA], [BPP] [1], [2]
  HypT-Met-oxidized activator metNp Sigma70 nd nd metN, metI, metQ nd nd [GEA], [BPP] [1], [2]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation