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Synonyms: FliZ |
Summary:
The transcriptional repressor FliZ controls the transcription of genes involved in the regulation of curli expression and the motility system [1, 2]. During the post-exponential growth phase, this regulator is an abundant protein in the genome, with about 21,500 molecules per cell. Transcriptome expression analysis showed a global antagonistic effect between FliZ and σS that resulted in physiological traits, including flagellum-mediated motility and curli fimbria-mediated adhesion [1, 2]. Overexpression of FliZ slightly increased polyP accumulation [3]. Moreover, FliZ interferes with binding within σS-dependent promoters, can also discriminate vegetative promoters, and can recognize alternative σS promoter-like sequences [2]. The C-terminal domain of FliZ contains an α-helix that is similar to helix 3.0 of σS, and this structure promotes DNA binding [2]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Connectivity class: | Local Regulator | ||||||||||||
Gene name: | fliZ | ||||||||||||
Genome position: | 2000473-2001024 | ||||||||||||
Length: | 552 bp / 183 aa | ||||||||||||
Operon name: | fliAZ-tcyJ | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | csgA, csgB, csgC, csgD, csgE, csgF, csgG, flhC, flhD, gadB, gadC, gadE, gadF, hdeA, hdeB, mdtE, mdtF, mlrA, osmY, pdeR, yhiD | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
Transcription related (6)
activator (4)
pH (4)
fimbri, pili (3)
defense/survival (3)
Read more >
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Regulated operon(s) | csgBAC, csgDEFG, flhDC, gadBC, gadEF-mdtEF, hdeAB-yhiD, mlrA, osmY, pdeR | ||||||
First gene in the operon(s) | csgB, csgD, flhD, gadB, gadE, hdeA, mlrA, osmY, pdeR | ||||||
Simple and complex regulons | AcrR,CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsAB,YjjQ AdiY,CRP,Fis,FliZ,GadE,GadW,GadX,RcsB BasR,BolA,BtsR,CRP,CpxR,Cra,CsgD,FliZ,H-NS,IHF,MlrA,MqsA,OmpR,RcdA,RcsAB,RstA,ppGpp BasR,BtsR,CRP,CpxR,Cra,CsgD,FliZ,H-NS,IHF,MlrA,MqsA,OmpR,RcdA,RcsAB,RstA BtsR,CpxR,CsgD,FliZ Read more > | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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FliZ | repressor | csgBp | Sigma70 | nd | nd | csgB, csgA, csgC | nd | nd | [GEA], [BPP] | [1] | ||
FliZ | repressor | csgBp2 | Sigma38 | nd | nd | csgB, csgA, csgC | nd | nd | [GEA], [BPP] | [1] | ||
FliZ | repressor | csgDp | Sigma38 | nd | nd | csgD, csgE, csgF, csgG | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | csgDp1 | Sigma70 | nd | nd | csgD, csgE, csgF, csgG | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | csgDp2 | Sigma70 | nd | nd | csgD, csgE, csgF, csgG | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | csgDp3 | Sigma38 | nd | nd | csgD, csgE, csgF, csgG | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | flhDp | Sigma70 | 12.0 | -187.0 | flhD, flhC |
agtacagttgCGTCGATTTAGGAAAAATCTTAGATAAGTGtaaagaccca
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1978370 | 1978399 | [GEA], [BPP] | [2] | |
FliZ | repressor | gadBp | Sigma70 | nd | nd | gadB, gadC | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | gadBp2 | Sigma38 | nd | nd | gadB, gadC | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | gadEp2 | Sigma38 | 9.5 | -12.5 | gadE, gadF, mdtE, mdtF |
aataatgaaaAGGATGACATATTCGAAACGATAACGGCTAAGGAGCAAGTTATGATTTTTCTCATGACGaaagattctt
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3658325 | 3658383 | [GEA], [BPP], [SM] | [2] | |
FliZ | repressor | hdeAp | Sigma70 | 8.0 | -44.0 | hdeA, hdeB, yhiD |
catatacagaAAACCAGGTTATAACCTCAGTGTCGAAATTGATTCGTGACGGCTCTTTCACTTTATagttgaggat
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3656757 | 3656812 | [GEA], [BPP] | [2] | |
FliZ | repressor | hdeAp2 | Sigma38 | 8.0 | -44.0 | hdeA, hdeB, yhiD |
catatacagaAAACCAGGTTATAACCTCAGTGTCGAAATTGATTCGTGACGGCTCTTTCACTTTATagttgaggat
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3656757 | 3656812 | [GEA], [BPP] | [2] | |
FliZ | repressor | mlrAp | Sigma70 | -10.0 | -36.0 | mlrA |
acctggttcgCAAAACTGCGTCTAAAGTTAAACCGGGACCtcgcgagcaa
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2214816 | 2214845 | [GEA], [BPP], [SM] | [1], [2] | |
FliZ | repressor | mlrAp2 | Sigma38 | -10.0 | -36.0 | mlrA |
acctggttcgCAAAACTGCGTCTAAAGTTAAACCGGGACCtcgcgagcaa
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2214816 | 2214845 | [GEA], [BPP], [SM] | [1], [2] | |
FliZ | repressor | osmYp | Sigma70 | nd | nd | osmY | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | osmYp2 | Sigma38 | nd | nd | osmY | nd | nd | [GEA], [BPP] | [1], [2] | ||
FliZ | repressor | pdeRp | Sigma38 | -37.5 | -138.5 | pdeR |
atccaggcagATTTTTTAACTGACTTTCGTTTGAAAACTGGCGTTTTTCCAAAACTGGAttacaaataa
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1346857 | 1346905 | [GEA], [BPP], [SM] | [1], [2] |
Evolutionary conservation of regulatory elements | ![]() |
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