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BtsR DNA-binding transcriptional activator

Synonyms: BtsR-Phosphorylated
Summary:
YehT has similarity to two-component system response regulator proteins [2]. Overproduction causes a drug resistance phenotype [2, 3].


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
BtsR-Phosphorylated Functional   [APPHINH], [IEP], [IPI] [1]
Evolutionary Family: LytTR
Sensing class: External-Two-component systems
Connectivity class: Local Regulator
Gene name: btsR
  Genome position: 2212243-2212962
  Length: 720 bp / 239 aa
Operon name: btsSR
TU(s) encoding the TF:
Transcription unit        Promoter
btsSR
null


Regulon       
Regulated gene(s) btsT
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
Porters (Uni-, Sym- and Antiporters) (1)
membrane (1)
Regulated operon(s) btsT
First gene in the operon(s) btsT
Simple and complex regulons BtsR,CRP
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[BtsR,+](1)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  BtsR-Phosphorylated activator yjiYp Sigma38 -62.0 -150.5 btsT
ggtaaataacTGAGTGGTTATTTTAGGGATGTAAGCGGTcagttttgcg
4591415 4591444 [BPP], [GEA], [SM] [1]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [APPHINH] Assay of protein purified to homogeneity from its native host

 [IEP] Inferred from expression pattern

 [IPI] Inferred from physical interaction

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis

 [SM] Site mutation



Reference(s)    

 [1] Kraxenberger T., Fried L., Behr S., Jung K., 2012, First insights into the unexplored two-component system YehU/YehT in Escherichia coli., J Bacteriol 194(16):4272-84

 [2] Hirakawa H., Nishino K., Hirata T., Yamaguchi A., 2003, Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli., J Bacteriol 185(6):1851-6

 [3] Hirakawa H., Nishino K., Yamada J., Hirata T., Yamaguchi A., 2003, Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli., J Antimicrob Chemother 52(4):576-82



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