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YedW DNA-binding transcriptional dual regulator

Synonyms: YedW-Phosphorylated


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
YedW-Phosphorylated     nd nd
Evolutionary Family: OmpR
Sensing class: External-Two-component systems
Connectivity class: Local Regulator
Gene name: yedW
  Genome position: 2038152-2038823
  Length: 672 bp / 223 aa
Operon name: yedWV
TU(s) encoding the TF:
Transcription unit        Promoter
yedWV
null


Regulon       
Regulated gene(s) cusA, cusB, cusC, cusF, cusR, cusS, cyoA, cyoB, cyoC, cyoD, cyoE, yedX
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (7)
aerobic respiration (5)
electron acceptors (4)
Oxidoreduction-driven Active Transporters (3)
Porters (Uni-, Sym- and Antiporters) (1)
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Regulated operon(s) cusCFBA, cusRS, cyoABCDE, yedX
First gene in the operon(s) cusC, cusR, cyoA, yedX
Simple and complex regulons ArcA,CRP,Cra,CusR,FNR,Fur,GadE,PdhR,YedW
CusR,PhoB,YedW
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[YedW,-](1)
[YedW,+](3)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  YedW-Phosphorylated activator cusCp Sigma70 nd nd cusC, cusF, cusB, cusA nd nd [HIBSCS] [1]
  YedW-Phosphorylated activator cusRp Sigma70 nd nd cusR, cusS nd nd [HIBSCS] [1]
  YedW-Phosphorylated repressor cyoAp Sigma70 69.5 25.5 cyoA, cyoB, cyoC, cyoD, cyoE
tcaggaaataCAATAAAAGTTTGGGATGgttgtcatta
451576 451593 [GEA], [HIBSCS] [1]
  YedW-Phosphorylated activator yedXp Sigma70 38.5 -78.5 yedX
cagcctggttCATTACAAAATTGTAATGctgctgtaag
2038869 2038886 [BPP], [GEA], [HIBSCS] [1]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [HIBSCS] Human inference based on similarity to consensus sequences

 [GEA] Gene expression analysis

 [BPP] Binding of purified proteins



Reference(s)    

 [1] Urano H., Umezawa Y., Yamamoto K., Ishihama A., Ogasawara H., 2015, Cooperative regulation of the common target genes between H2O2-sensing YedVW and Cu2+-sensing CusSR in Escherichia coli., Microbiology. 161(Pt 4):729-38



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