RegulonDB RegulonDB 9.3:Regulon Page
   

YjjQ DNA-binding transcriptional repressor

Synonyms: YjjQ
Summary:
YjjQ is a transcriptional repressor of genes required for flagellar synthesis, capsule formation, and other genes related to virulence |CITS:[26078445]|. Repression is mediated by binding to a palindromic DNA motif. Episomal expression of yjjQ inhibits motility and biofilm formation |CITS:[26078445]|. YjjQ harbors a FixJ/NarL-type C-terminal helix-turn-helix DNA-binding domain |CITS:[20952573]| .
YjjQ may play a role in detoxification of methylglyoxal (MG) and dihydroxyacetone (DHA) |CITS: [17846588]|. YjjQ
belongs to the LuxR family of transcriptional regulators. The orthologous protein in avian pathogenic E. coli
|CITS: [15845486]| and in Salmonella enterica serovar Typhimurium |CITS: [16518469]| may play a role in
virulence.
A yjjQ insertion mutant increases the sensitivity of a gloA mutant to MG and DHA. A strain containing
only the yjjQ insertion mutation does not show increased sensitivity to MG or DHA |CITS: [17846588]|.
yjjQ is expressed in an operon together with bglJ |CITS: [18055596]|; it is located upstream of
bglJ, and thus the mutant phenotype of the yjjQ insertion mutant could be due to a polar effect on
bglJ.


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
YjjQ     nd nd
Evolutionary Family: LuxR/UhpA
Connectivity class: Local Regulator
Gene name: yjjQ
  Genome position: 4603477-4604202
  Length: 726 bp / 241 aa
Operon name: yjjQ-bglJ
TU(s) encoding the TF:
Transcription unit        Promoter
yjjQ-bglJ
yjjQp


Regulon       
Regulated gene(s) dgcN, flhC, flhD, gfcA, ompC, ybhL, yciX, yfiB, yfiR, ymiA
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc) (4)
flagellum (2)
Transcription related (2)
activator (2)
repressor (2)
Read more >
Regulated operon(s) flhDC, gfcA, ompC, ybhL, yfiR-dgcN-yfiB, ymiA-yciX
First gene in the operon(s) flhD, gfcA, ompC, ybhL, yfiR, ymiA
Simple and complex regulons CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsAB,YjjQ
CpxR,EnvY,IHF,Lrp,OmpR,YjjQ
YjjQ
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[YjjQ,-](6)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  YjjQ repressor flhDp Sigma70 11.0 -188.0 flhD, flhC
ttgcgtcgatTTAGGAAAAATCTTAgataagtgta
1978378 1978392 [AIBSCS], [GEA], [SM] [1]
  YjjQ repressor gfcAp Sigma70 -49.0 -1007.0 gfcA
atagctttcgTAACAATTTCCTTATctttaatttg
1050744 1050758 [AIBSCS], [GEA] [1]
  YjjQ repressor gfcAp Sigma70 -16.0 -974.0 gfcA
tgtattttgcTAAGATTTATCTTATgctcacaagt
1050711 1050725 [AIBSCS], [GEA], [SM] [1]
  YjjQ repressor ompCp1 Sigma70 -64.0 -145.0 ompC
ctatagcgatAAATGAAACATCTTAaaagttttag
2312887 2312901 [AIBSCS], [GEA] [1]
  YjjQ repressor ybhLp Sigma70 2.0 -25.0 ybhL
gcagtatcctTAAGATATTCCTTATatcttcagga
819852 819866 [AIBSCS], [GEA] [1]
  YjjQ repressor yfiRp Sigma70 -65.0 -116.0 yfiR, dgcN, yfiB
aaattaaacaTAAGATTTTACTCATtgtgttttat
2741752 2741766 [AIBSCS], [GEA] [1]
  YjjQ repressor ymiAp Sigma70 -6.0 -40.0 ymiA, yciX
aaagtttcttTAGGATTTGTCTCATcgtatgatta
1335077 1335091 [AIBSCS], [GEA] [1]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [AIBSCS] Automated inference based on similarity to consensus sequences

 [GEA] Gene expression analysis

 [SM] Site mutation



Reference(s)    

 [1] Wiebe H., Gurlebeck D., Gross J., Dreck K., Pannen D., Ewers C., Wieler LH., Schnetz K., 2015, YjjQ Represses Transcription of flhDC and Additional Loci in Escherichia coli., J Bacteriol. 197(16):2713-20



RegulonDB