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UvrY DNA-binding transcriptional activator

Synonyms: UvrY-phosphorylated


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
UvrY-phosphorylated     nd nd
Evolutionary Family: LuxR/UhpA
Sensing class: External-Two-component systems
Connectivity class: Local Regulator
Gene name: uvrY
  Genome position: 1994703-1995359
  Length: 657 bp / 218 aa
Operon name: uvrYC
TU(s) encoding the TF:
Transcription unit        Promoter
uvrYC
uvrYp2


Regulon       
Regulated gene(s) csrB, csrC, luxS, uhpT, ydeP
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
RNA degradation (1)
posttranscriptional (1)
RNA related (1)
quorum sensing (1)
carbon compounds (1)
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Regulated operon(s) csrB, csrC, luxS, uhpT, ydeP
First gene in the operon(s) csrB, csrC, luxS, uhpT, ydeP
Simple and complex regulons CRP,UhpA,UvrY
CRP,UvrY
EvgA,H-NS,NagC,NarL,NarP,PhoP,RcsB,UvrY
UvrY
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[UvrY,+](2)


Transcription factor binding sites (TFBSs) arrangements       

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  UvrY-phosphorylated activator csrBp Sigma70 -183.0 -182.5 csrB
cccatctggtTGTGAGAGATCTCTTACAgactctgtag
2924698 2924715 [BPP], [GEA] [1]
  UvrY-phosphorylated activator csrCp nd -159.0 -159.5 csrC
ccatacgcttTGTGAGACATTGCCGATAgtctttatgc
4050868 4050885 [BPP], [GEA] [1]
  UvrY-phosphorylated activator luxSp2 nd nd nd luxS nd nd [BPP], [GEA] [2]
  UvrY-phosphorylated activator uhpTp Sigma70 nd nd uhpT nd nd [BPP], [GEA] [3]
  UvrY-phosphorylated activator ydePp Sigma70 nd nd ydeP nd nd [BPP], [GEA] [3]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    

 [BPP] Binding of purified proteins

 [GEA] Gene expression analysis



Reference(s)    

 [1] Zere TR., Vakulskas CA., Leng Y., Pannuri A., Potts AH., Dias R., Tang D., Kolaczkowski B., Georgellis D., Ahmer BM., Romeo T., 2015, Genomic Targets and Features of BarA-UvrY (-SirA) Signal Transduction Systems., PLoS One. 10(12):e0145035

 [2] Mitra A., Herren CD., Patel IR., Coleman A., Mukhopadhyay S., 2016, Integration of AI-2 Based Cell-Cell Signaling with Metabolic Cues in Escherichia coli., PLoS One. 11(6):e0157532

 [3] Yoshida M., Ishihama A., Yamamoto K., 2015, Cross talk in promoter recognition between six NarL-family response regulators of Escherichia coli two-component system., Genes Cells. 20(7):601-12



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