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| Synonyms: UvrY-phosphorylated, UvrY |
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Summary:
The protein belongs to the LuxR/UhpA family. This regulator participates in controlling several genes involved in the DNA repair system and carbon metabolism. UvrY has been shown to be the cognate response regulator for the BarA sensor protein. UvrY phosphorylated at the conserved Asp54 residue is the active form [1]. Z nucleotides [ZMP (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5-monophosphate) and/or ZTP (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5-triphosphate)] can act as direct phosphodonors to UvrY in vivo, activating it in a BarA-independent manner [1]. UvrY requires the presence of IHF for binding to csrB but not csrC [2] The genes regulated by this two-component sytem have yet to be identified. The signal the system responds to is also not known, but may be associated with hydrogen peroxide-mediated stress [5]. However, it has been reported that UvrY is phosphorylated at the transition from the exponential to stationary phase of growth (OD600 1.3) [1]. Only two targets of UvrY were found in a Genomic SELEX screening; they are located upstream of the genes csrB and csrC [6]. Read more > |
| Transcription factor |  |
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| TF conformation(s): |
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| Evolutionary Family: | LuxR/UhpA | |||||||||||||||||||||
| Sensing class: | External-Two-component systems | |||||||||||||||||||||
| Connectivity class: | Local Regulator | |||||||||||||||||||||
| Gene name: | uvrY | |||||||||||||||||||||
| Genome position: | 1994703-1995359 | |||||||||||||||||||||
| Length: | 657 bp / 218 aa | |||||||||||||||||||||
| Operon name: | uvrYC | |||||||||||||||||||||
| TU(s) encoding the TF: |
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| Regulon |
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| Regulated gene(s) | csrB, csrC, luxS, uhpT, ydeP | ||||||
| Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
RNA degradation (1)
posttranscriptional (1)
RNA related (1)
quorum sensing (1)
carbon compounds (1)
Read more >
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| Regulated operon(s) | csrB, csrC, luxS, uhpT, ydeP | ||||||
| First gene in the operon(s) | csrB, csrC, luxS, uhpT, ydeP | ||||||
| Simple and complex regulons | CRP,UhpA,UvrY CRP,UvrY EvgA,H-NS,NagC,NarL,NarP,PhoP,RcsB,UvrY IHF,UvrY UvrY | ||||||
| Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) | ||||||
| Transcription factor regulation |
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Transcription factor binding sites (TFBSs) arrangements
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| Evolutionary conservation of regulatory elements | |
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| Promoter-target gene evolutionary conservation |
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| Reference(s) |
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[EXP-IEP-GENE-EXPRESSION-ANALYSIS] Gene expression analysis