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Synonyms: UvrY, UvrY-Phosphorylated |
Summary:
The protein belongs to the LuxR/UhpA family. This regulator participates in controlling several genes involved in the DNA repair system and carbon metabolism. UvrY has been shown to be the cognate response regulator for the BarA sensor protein. UvrY requires the presence of IHF for binding to csrB but not csrC [1] The genes regulated by this two-component sytem have yet to be identified. The signal the system responds to is also not known, but may be associated with hydrogen peroxide-mediated stress [4]. |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | LuxR/UhpA | ||||||||||||||||||
Sensing class: | External-Two-component systems | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | uvrY | ||||||||||||||||||
Genome position: | 1994703-1995359 | ||||||||||||||||||
Length: | 657 bp / 218 aa | ||||||||||||||||||
Operon name: | uvrYC | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | csrB, csrC, luxS, uhpT, ydeP | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
RNA degradation (1)
posttranscriptional (1)
RNA related (1)
quorum sensing (1)
carbon compounds (1)
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Regulated operon(s) | csrB, csrC, luxS, uhpT, ydeP | ||||||
First gene in the operon(s) | csrB, csrC, luxS, uhpT, ydeP | ||||||
Simple and complex regulons | CRP,UhpA,UvrY CRP,UvrY EvgA,H-NS,NagC,NarL,NarP,PhoP,RcsB,UvrY IHF,UvrY UvrY | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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UvrY-Phosphorylated | activator | csrBp | Sigma70 | -183.0 | -183.0 | csrB |
ccccatctggTTGTGAGAGATCTCTTACAgactctgtag
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2924698 | 2924716 | [BPP], [GEA] | [1] | |
UvrY-Phosphorylated | activator | csrCp | nd | -159.0 | -159.0 | csrC |
ccatacgcttTGTGAGACATTGCCGATAGtctttatgcg
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4050868 | 4050886 | [BPP], [GEA] | [1] | |
UvrY-Phosphorylated | activator | luxSp2 | nd | nd | nd | luxS | nd | nd | [BPP], [GEA] | [2] | ||
UvrY-Phosphorylated | activator | uhpTp | Sigma70 | nd | nd | uhpT | nd | nd | [BPP], [GEA] | [3] | ||
UvrY-Phosphorylated | activator | ydePp | Sigma70 | nd | nd | ydeP | nd | nd | [BPP], [GEA] | [3] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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