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Fur DNA-binding transcriptional dual regulator

Synonyms: Fur-Fe2+, Fur-Mn2+, Fur
Summary:
The transcriptional activator FUR, for "Ferric Uptake Regulation," is capable of controlling its own synthesis [8, 12, 29, 35]and controls the transcription of genes involved in iron homeostasis [8, 9, 10, 12, 22, 26, 31, 32, 50]and a minor sigma factor that initiates transcription of ferric citrate transport genes in response to the presence of periplasmic iron(III) dicitrate [8, 22, 23] This regulator also participates in the regulation of transcription of many other genes involved in different cellular functions, including the following: flagellum chemotaxis [14] methionine biosynthesis [14] acid and oxidative stresses [10, 46] metal ion stress [40, 44, 56] resistance to cobalt and nickel [] the tricarboxylic acid cycle [17, 34] glycolysis and gluconeogenesis [10] respiration [14, 17, 34] porins [17] purine metabolism [14] 2,3-dihydroxybenzoate biosynthesis [15] and phage DNA packaging [10] Based on transcriptome analysis, expression levels of a set of genes regulated by Fur change substantially in response to antibiotic treatment [] Iron homeostasis influences the evolution of ciprofloxacin resistance [] FUR is a transcriptional repressor but also can be an activator; the positive regulation of this regulator is mediated by the indirect effect of RhyB, which is an antisense small RNA [45, 57, 58, 59] FUR is a sensor of the concentration of intracellular iron, and the genetic repression occurs when the physiological inducer, iron (Fe2+), binds to FUR.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
Fur Non-Functional   Apo [IDA] [1]
Fur-Fe2+ Functional Allosteric Holo [GEA], [IDA], [IPI] [1], [2], [3], [4], [5], [6]
Fur-Mn2+ Functional Allosteric Holo [IDA] [1]
Evolutionary Family: Fur
Sensing class: External sensing using transported metabolites
Connectivity class: Local Regulator
Gene name: fur
  Genome position: 710200-710646
  Length: 447 bp / 148 aa
Operon name: fldA-uof-fur
TU(s) encoding the TF:
Transcription unit        Promoter
fldA-uof-fur
fldAp
fur
furpa
fur
furpb
uof-fur
uofp


Regulon       
Regulated gene(s) amtB, aspC, cirA, crl_1, cyoA, cyoB, cyoC, cyoD, cyoE, entA, entB, entC, entD, entE, entF, entH, entS, exbB, exbD, fecA, fecB, fecC, fecD, fecE, fecI, fecR, feoA, feoB, feoC, fepA, fepB, fepC, fepD, fepE, fepG, fes, fhuA, fhuB, fhuC, fhuD, fhuE, fhuF, fiu, flhC, flhD, fnr, ftnA, fumB, fumC, fur, garK, garL, garP, garR, gdhA, glnD, glnK, gltB, gltD, gltF, gnd, gpmA, grcA, gspC, gspD,
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Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (33)
Fe aquisition (28)
Putative uncharacterized transport protein (12)
Transcription related (11)
aerobic respiration (10)
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Regulated operon(s) aspC, cirA, crl_1, cyoABCDE, dcuB-fumB, entCEBAH, entS, exbBD, fecABCDE, fecIR, feoABC, fepA-entD, fepB, fepDGC, fes-ybdZ-entF-fepE, fhuACDB, fhuE, fhuF, fiu, fldA-uof-fur, flhDC, fnr, ftnA, fumAC, garPLRK-rnpB, gdhA, glnK-amtB, gltBDF, gnd, gpmA, grcA, gspCDEFGHIJKLMO, hmp, katE, katG, map-glnD-dapD, metH, metJ, mntH, mntP, nac, ndh, nlpD-rpoS, nohA-ydfN-tfaQ, nrdHIEF, ompF, oppABCDF, pdhR-aceEF-lpd, purR, pyrC, rcnAB, ryhB, sdhCDAB-sucABCD, sodA, soxR, soxS, sufABCDSE, tonB, ygaC, yhhY, yjjZ, yqjH, zinT, zwf
First gene in the operon(s) aspC, cirA, cirA, crl_1, cyoA, entC, entS, exbB, exbD, fecA, fecI, feoA, fepA, fepB, fepD, fes, fhuA, fhuE, fhuF, fiu, flhD, fnr, ftnA, fumB, fumC, fur, fur, garP, gdhA, glnD, glnK, gltB, gnd, gpmA, grcA, gspC, hmp, katE, katG, lpd, metH, metJ, mntH, mntP, nac, ndh, nohA, nrdH, ompF, oppA, purR, pyrC, rcnA, rpoS, ryhB, sdhC, sodA, soxR, soxS, sufA, tonB, ygaC, yhhY, yjjZ, yqjH,
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Simple and complex regulons AcrR,CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsAB,YjjQ
AcrR,FNR,Fur,SoxR
AcrR,FNR,Fur,SoxR,SoxS
AdiY,ArgR,CRP,FNR,Fur,GadE,HdfR,IHF,Lrp,Nac
ArcA,CRP,Cra,CusR,FNR,Fis,Fur,GadE,HprR,PdhR
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Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[Fur,-](41)
[Fur,+](4)
[Fur,+-](1)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  Fur-Fe2+ repressor aspCp nd nd 985709.0 aspC nd nd [GEA] [7]
  Fur-Fe2+ repressor cirAp1 Sigma70 -35.0 -195.0 cirA
tgcaaacgatAACAATTATCAATCCAAATgttaaatttt
2246955 2246973 [BPP], [GEA], [HIBSCS] [8], [9], [10], [11]
  Fur-Fe2+ repressor cirAp1 Sigma70 -29.0 -189.0 cirA
cgataatgcaAACGATAACAATTATCAATccaaatgtta
2246949 2246967 [BPP], [GEA], [HIBSCS] [8], [9], [10], [11]
  Fur-Fe2+ repressor cirAp1 Sigma70 -23.0 -183.0 cirA
gcgtaacgatAATGCAAACGATAACAATTatcaatccaa
2246943 2246961 [BCE], [HIBSCS] [8]
  Fur-Fe2+ repressor cirAp1 Sigma70 -17.0 -177.0 cirA
attgcggcgtAACGATAATGCAAACGATAacaattatca
2246937 2246955 [AIBSCS], [GEA] [10], [11], [12]
  Fur-Fe2+ repressor cirAp2 Sigma70 -22.0 -195.0 cirA
tgcaaacgatAACAATTATCAATCCAAATgttaaatttt
2246955 2246973 [BPP], [GEA], [HIBSCS] [8], [9], [10], [11]
  Fur-Fe2+ repressor cirAp2 Sigma70 -16.0 -189.0 cirA
cgataatgcaAACGATAACAATTATCAATccaaatgtta
2246949 2246967 [BPP], [GEA], [HIBSCS] [8], [9], [10], [11]
  Fur-Fe2+ repressor cirAp2 Sigma70 -4.0 -177.0 cirA
attgcggcgtAACGATAATGCAAACGATAacaattatca
2246937 2246955 [AIBSCS], [GEA] [10], [11], [12]
  Fur-Fe2+ repressor crlp1 Sigma38, Sigma70 nd -257829.0 crl_1 nd nd [BPP], [GEA] [13]
  Fur-Fe2+ repressor cyoAp Sigma70 -213.0 -256.0 cyoA, cyoB, cyoC, cyoD, cyoE
aacaattattTAACAAATAATTATCATTAgagtgacaac
451857 451875 [AIBSCS], [GEA] [7], [14]
  Fur-Fe2+ repressor entCp Sigma70 -100.0 -154.0 entC, entE, entB, entA, entH
cgaatccatcAATAATGCTTCTCATTTTCattgtaacca
624722 624740 [AIBSCS], [GEA] [15], [16], [17]
  Fur-Fe2+ repressor entCp Sigma70 13.0 -42.0 entC, entE, entB, entA, entH
agcgaccgaaAATATAAATGATAATCATTattaaagcct
624834 624852 [AIBSCS], [BPP], [GEA], [HIBSCS] [8], [12], [15], [17]
  Fur-Fe2+ repressor entCp Sigma70 16.0 -39.0 entC, entE, entB, entA, entH
gaccgaaaatATAAATGATAATCATTATTaaagccttta
624837 624855 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor entCp Sigma70 19.0 -36.0 entC, entE, entB, entA, entH
cgaaaatataAATGATAATCATTATTAAAgcctttatca
624840 624858 [BPP], [HIBSCS] [8], [12], [15]
  Fur-Fe2+ repressor entCp Sigma70 25.0 -30.0 entC, entE, entB, entA, entH
tataaatgatAATCATTATTAAAGCCTTTatcattttgt
624846 624864 [BPP], [HIBSCS] [12], [15]
  Fur-Fe2+ repressor entCp Sigma70 31.0 -24.0 entC, entE, entB, entA, entH
tgataatcatTATTAAAGCCTTTATCATTttgtggagga
624852 624870 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor entCp Sigma70 58.0 3.0 entC, entE, entB, entA, entH
ttttgtggagGATGATATGGATACGTCACtggctgagga
624879 624897 [BPP] [15]
  Fur-Fe2+ dual entSp1 Sigma70 -50.0 -92.0 entS
tacgaacttcCATGATAATGAAATTAATTatcgttatcg
622199 622217 [BPP], [HIBSCS] [8]
  Fur-Fe2+ dual entSp1 Sigma70 -44.0 -86.0 entS
taagatcgatAACGATAATTAATTTCATTatcatggaag
622205 622223 [BPP], [GEA], [HIBSCS] [8], [18], [19], [20]
  Fur-Fe2+ dual entSp1 Sigma70 -38.0 -80.0 entS
tgataatgaaATTAATTATCGTTATCGATcttatttgga
622211 622229 [BPP], [HIBSCS] [8]
  Fur-Fe2+ dual entSp1 Sigma70 -32.0 -74.0 entS
tgaaattaatTATCGTTATCGATCTTATTtggatatgtt
622217 622235 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor exbBp Sigma70 -46.0 -76.0 exbB, exbD
tcgaattgatAGTCGTTCTCATTACTATTtgcatactgc
3152051 3152069 [AIBSCS] [12]
  Fur-Fe2+ repressor exbBp Sigma70 -40.0 -70.0 exbB, exbD
acgacgtcgaATTGATAGTCGTTCTCATTactatttgca
3152045 3152063 [BPP], [HIBSCS] [8], [12], [21]
  Fur-Fe2+ repressor exbDp nd -46.0 -193.0 exbD
gaatcgctgcCACGAGGCCGATTGCCGTTgctaacagag
3151427 3151445 [HIBSCS] [12], [21]
  Fur-Fe2+ repressor fecAp Sigma19 -29.0 -79.0 fecA, fecB, fecC, fecD, fecE
ggacaatcgaAATAAGAATTATTTTCCTTacagtggtga
4516747 4516765 [AIBSCS], [BPP] [8], [12]
  Fur-Fe2+ repressor fecAp Sigma19 -26.0 -76.0 fecA, fecB, fecC, fecD, fecE
aaaggacaatCGAAATAAGAATTATTTTCcttacagtgg
4516744 4516762 [AIBSCS], [BPP], [GEA], [HIBSCS] [12], [17], [22]
  Fur-Fe2+ repressor fecAp Sigma19 -23.0 -73.0 fecA, fecB, fecC, fecD, fecE
taaaaaggacAATCGAAATAAGAATTATTttccttacag
4516741 4516759 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor fecIp Sigma70 -14.0 -61.0 fecI, fecR
tatgagaatgGTTATCATTACAATTGGAAataaaattgt
4518287 4518305 [BPP], [HIBSCS] [8], [22], [23], [24]
  Fur-Fe2+ repressor fecIp Sigma70 -10.0 -57.0 fecI, fecR
ttaatatgagAATGGTTATCATTACAATTggaaataaaa
4518283 4518301 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor fecIp Sigma70 -7.0 -54.0 fecI, fecR
atattaatatGAGAATGGTTATCATTACAattggaaata
4518280 4518298 [AIBSCS], [BPP], [GEA], [SM] [8], [23], [25]
  Fur-Fe2+ repressor fecIp Sigma70 -4.0 -51.0 fecI, fecR
gtcatattaaTATGAGAATGGTTATCATTacaattggaa
4518277 4518295 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor feoAp Sigma70 -17.0 -123.0 feoA, feoB, feoC
tattgctgatAGAAACCATTCTCATTATCattgtgttgt
3540031 3540049 [GEA], [HIBSCS] [26]
  Fur-Fe2+ repressor fepAp Sigma70 -18.0 -191.0 fepA, entD
attgattgcaGAAATATATTGATAATATTattgataact
612676 612694 [BPP], [GEA], [HIBSCS] [7], [8], [12]
  Fur-Fe2+ repressor fepAp Sigma70 -11.0 -184.0 fepA, entD
gcagaaatatATTGATAATATTATTGATAactatttgca
612669 612687 [AIBSCS], [BPP], [GEA], [HIBSCS] [7], [8], [12], [17]
  Fur-Fe2+ repressor fepAp Sigma70 -5.0 -178.0 fepA, entD
atatattgatAATATTATTGATAACTATTtgcatttgca
612663 612681 [AIBSCS], [BPP], [GEA], [HIBSCS] [7], [8], [12], [17]
  Fur-Fe2+ repressor fepAp Sigma70 2.0 -172.0 fepA, entD
tgataatattATTGATAACTATTTGCATTtgcaatagcg
612657 612675 [BPP], [GEA], [HIBSCS] [7], [8], [12], [17]
  Fur-Fe2+ repressor fepAp Sigma70 9.0 -165.0 fepA, entD
attattgataACTATTTGCATTTGCAATAgcgtaatggc
612650 612668 [AIBSCS], [BPP], [GEA], [HIBSCS] [7], [8], [10], [12], [17], [27]
  Fur-Fe2+ repressor fepBp Sigma70 -13.0 -230.0 fepB
caataatgctTCTCATTTTCATTGTAACCacaaccagat
624731 624749 [BPP], [HIBSCS] [15]
  Fur-Fe2+ repressor fepBp Sigma70 -7.0 -224.0 fepB
atccatcaatAATGCTTCTCATTTTCATTgtaaccacaa
624725 624743 [AIBSCS], [BPP], [GEA], [HIBSCS], [SM] [8], [10], [12], [15]
  Fur-Fe2+ repressor fepBp Sigma70 -1.0 -218.0 fepB
atgcgaatccATCAATAATGCTTCTCATTttcattgtaa
624719 624737 [AIBSCS], [BPP], [GEA], [HIBSCS] [8], [10], [12], [15]
  Fur-Fe2+ repressor fepDp1 Sigma70 9.0 -37.0 fepD, fepG, fepC
aacatatccaAATAAGATCGATAACGATAattaatttca
622217 622235 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor fepDp1 Sigma70 15.0 -31.0 fepD, fepG, fepC
tccaaataagATCGATAACGATAATTAATttcattatca
622211 622229 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor fepDp1 Sigma70 21.0 -25.0 fepD, fepG, fepC
cttccatgatAATGAAATTAATTATCGTTatcgatctta
622205 622223 [BPP], [GEA], [HIBSCS] [8], [18], [19], [20]
  Fur-Fe2+ repressor fepDp1 Sigma70 27.0 -19.0 fepD, fepG, fepC
cgataacgatAATTAATTTCATTATCATGgaagttcgta
622199 622217 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor fesp Sigma70 -28.0 -78.0 fes, ybdZ, entF, fepE
gccattacgcTATTGCAAATGCAAATAGTtatcaataat
612650 612668 [AIBSCS], [BPP], [GEA], [HIBSCS] [7], [8], [10], [12], [17], [27], [28]
  Fur-Fe2+ repressor fesp Sigma70 -21.0 -71.0 fes, ybdZ, entF, fepE
cgctattgcaAATGCAAATAGTTATCAATaatattatca
612657 612675 [BPP], [GEA], [HIBSCS] [7], [8], [12], [17]
  Fur-Fe2+ repressor fesp Sigma70 -15.0 -65.0 fes, ybdZ, entF, fepE
tgcaaatgcaAATAGTTATCAATAATATTatcaatatat
612663 612681 [AIBSCS], [BPP], [GEA], [HIBSCS] [7], [8], [12], [17]
  Fur-Fe2+ repressor fesp Sigma70 -9.0 -59.0 fes, ybdZ, entF, fepE
tgcaaatagtTATCAATAATATTATCAATatatttctgc
612669 612687 [AIBSCS], [BPP], [GEA], [HIBSCS] [7], [8], [12], [17]
  Fur-Fe2+ repressor fesp Sigma70 -2.0 -52.0 fes, ybdZ, entF, fepE
agttatcaatAATATTATCAATATATTTCtgcaatcaat
612676 612694 [BPP], [GEA], [HIBSCS] [7], [8], [12]
  Fur-Fe2+ repressor fhuAp Sigma70 -3.0 -45.0 fhuA, fhuC, fhuD, fhuB
atcttatcttTATAATAATCATTCTCGTTtacgttatca
167430 167448 [BPP], [GEA], [HIBSCS] [8], [29], [30]
  Fur-Fe2+ repressor fhuEp nd -10.0 -106.0 fhuE
tgtaaatgcaAATGAGAAATATACGCATTcatatttgtc
1161648 1161666 [AIBSCS] [12]
  Fur-Fe2+ repressor fhuEp nd 15.0 -82.0 fhuE
atttagtgtgCGAATAATTTTGTTTGTAAatgcaaatga
1161624 1161642 [HIBSCS] [12], [31]
  Fur-Fe2+ repressor fhuFp Sigma70 -85.0 -116.0 fhuF
catctctttcATTGATAATGATAACCAATatcatatgat
4605770 4605788 [AIBSCS], [BPP], [GEA] [8], [10], [32]
  Fur-Fe2+ repressor fhuFp Sigma70 -79.0 -110.0 fhuF
aaaattatcaTATGATATTGGTTATCATTatcaatgaaa
4605764 4605782 [AIBSCS], [BPP], [GEA], [HIBSCS] [8], [10], [32]
  Fur-Fe2+ repressor fhuFp Sigma70 -62.0 -93.0 fhuF
ctggcttgcaAATGATAAAAATTATCATAtgatattggt
4605747 4605765 [AIBSCS], [BPP], [GEA], [HIBSCS] [8], [10], [32]
  Fur-Fe2+ repressor fhuFp Sigma70 -56.0 -87.0 fhuF
atcatatgatAATTTTTATCATTTGCAAGccagataaat
4605741 4605759 [AIBSCS], [BPP], [GEA] [8], [10], [32]
  Fur-Fe2+ repressor fiup Sigma70 -6.0 -123.0 fiu
tgataataatTTTGATAAGCATTATCACTtggagcgatt
841645 841663 [HIBSCS] [12]
  Fur-Fe2+ repressor fiup Sigma70 2.0 -116.0 fiu
gtgaaagtgaTAATAATTTTGATAAGCATtatcacttgg
841638 841656 [HIBSCS] [12]
  Fur-Fe2+ repressor fiup Sigma70 3.0 -115.0 fiu
cgtgaaagtgATAATAATTTTGATAAGCAttatcacttg
841637 841655 [HIBSCS] [12]
  Fur-Fe2+ repressor fiup Sigma70 12.0 -106.0 fiu
gatagtgctcGTGAAAGTGATAATAATTTtgataagcat
841628 841646 [HIBSCS] [12]
  Fur-Fe2+ repressor flhDp Sigma70 115.0 -84.0 flhD, flhC
ggaagccccgGTAAAAAATAATTAGCATTagaatagttg
1978272 1978290 [AIBSCS] [14]
  Fur-Fe2+ repressor fnrp Sigma70 nd 1399526.0 fnr nd nd [GEA] [7]
  Fur-Fe2+ activator ftnAp Sigma70 -89.0 -123.0 ftnA
tgattaaagaAATAGCGGTAATGCGTTTTattcccattc
1988584 1988602 [BPP], [GEA], [HIBSCS] [33]
  Fur-Fe2+ activator ftnAp Sigma70 -83.0 -116.5 ftnA
aagaaatagcGGTAATGCGTTTTATTCCCattcgtattt
1988590 1988609 [BPP], [GEA], [HIBSCS] [33]
  Fur-Fe2+ activator ftnAp Sigma70 -77.0 -111.0 ftnA
tagcggtaatGCGTTTTATTCCCATTCGTatttttaata
1988596 1988614 [BPP], [GEA], [HIBSCS] [33]
  Fur-Fe2+ activator ftnAp Sigma70 -71.0 -105.0 ftnA
taatgcgtttTATTCCCATTCGTATTTTTaataattgaa
1988602 1988620 [BPP], [GEA], [HIBSCS] [33]
  Fur-Fe2+ activator ftnAp Sigma70 -65.0 -99.0 ftnA
gttttattccCATTCGTATTTTTAATAATtgaagtttat
1988608 1988626 [BPP], [GEA], [HIBSCS] [33]
  Fur-Fe2+ activator fumBp Sigma70 nd 4347326.0 fumB nd nd [GEA] [34]
  Fur-Fe2+ repressor fumCp Sigma38 nd 1686588.0 fumC nd nd [GEA] [7]
  Fur-Fe2+ repressor furpa Sigma70 -7.0 -77.0 fur
ctcttgagatAATGCGTATCATTATAGAAttgccacgcc
710714 710732 [BPP], [HIBSCS] [8], [12], [35]
  Fur-Fe2+ repressor furpa Sigma70 -1.0 -71.0 fur
aatttgctctTGAGATAATGCGTATCATTatagaattgc
710708 710726 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor furpb Sigma70 1.0 -77.0 fur
ctcttgagatAATGCGTATCATTATAGAAttgccacgcc
710714 710732 [BPP], [HIBSCS] [8], [12], [35]
  Fur-Fe2+ repressor furpb Sigma70 7.0 -71.0 fur
aatttgctctTGAGATAATGCGTATCATTatagaattgc
710708 710726 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor garPp Sigma70 90.0 62.0 garP, garL, garR, garK, rnpB
cggtaacaatAAAAATAATCAGTAATATTaaatagcggg
3274836 3274854 [BPP], [HIBSCS] [8]
  Fur-Fe2+ dual gdhAp1 Sigma70 nd -1842371.0 gdhA nd nd [GEA] [7]
  Fur-Fe2+ dual gdhAp1 Sigma70 nd -1842371.0 gdhA nd nd [GEA] [7]
  Fur-Fe2+ repressor glnDp nd nd 188650.0 glnD nd nd [GEA] [7]
  Fur-Fe2+ dual glnKp Sigma54 nd -472598.0 glnK, amtB nd nd [GEA] [7]
  Fur-Fe2+ dual glnKp Sigma54 nd -472598.0 glnK, amtB nd nd [GEA] [7]
  Fur-Fe2+ repressor gltBp Sigma70 nd -3354725.0 gltB, gltD, gltF nd nd [GEA] [7]
  Fur-Fe2+ repressor gndp Sigma70 nd 2101268.0 gnd nd nd [GEA] [7]
  Fur-Fe2+ repressor gpmAp Sigma70, Sigma38 3.0 -35.0 gpmA
atcatcttttAATGATAATAATTCTCATTatattgccgc
787621 787639 [AIBSCS], [BPP], [GEA], [HIBSCS] [8], [10]
  Fur-Fe2+ repressor gpmAp Sigma70, Sigma38 6.0 -32.0 gpmA
caaatcatctTTTAATGATAATAATTCTCattatattgc
787618 787636 [AIBSCS], [GEA] [10]
  Fur-Fe2+ repressor grcAp1 Sigma70 nd 2716449.0 grcA nd nd [GEA] [7]
  Fur-Fe2+ repressor gspCp3 Sigma70 156.0 108.0 gspC, gspD, gspE, gspF, gspG, gspH, gspI, gspJ, gspK, gspL, gspM, gspO
gattatttttAATGTGAATTATTTCCATAcaactatagt
3455677 3455695 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor hmpAp Sigma38 6.0 -33.0 hmp
tataagatgcATTTGAGATACATCAATTAagatgcaaaa
2685793 2685811 [AS], [GEA], [HIBSCS], [IMP] [32], [36], [37]
  Fur-Fe2+ activator katEp Sigma38 nd -1813867.0 katE nd nd [IEP] [38]
  Fur-Fe2+ activator katGp Sigma70 nd -4133835.0 katG nd nd [IEP] [38]
  Fur-Fe2+ dual lpdAp Sigma70 nd -127912.0 lpd nd nd [GEA] [7]
  Fur-Fe2+ dual lpdAp Sigma70 nd -127912.0 lpd nd nd [GEA] [7]
  Fur-Fe2+ repressor metHp Sigma70 -124.0 -169.0 metH
ttttctgtatCGTGGAAATCATTTTCATTtttattgtta
4223650 4223668 [AIBSCS] [14]
  Fur-Fe2+ repressor metJp2 Sigma70 -1.0 -135.0 metJ
cacctgtcggCGTGATAATGCATATAATTttaacggcta
4128521 4128539 [AIBSCS] [14]
  Fur-Fe2+ repressor mntHp Sigma70, Sigma70 -31.5 -60.0 mntH
atgccaaacgAGAATGATTATCAAATTCatttaaatgg
2512757 2512775 [AIBSCS], [HIBSCS], [IGI] [39], [40]
  Fur-Fe2+ activator mntPp Sigma70 -71.5 -300.0 mntP
atataaatccAAATGAAAATCGTTATCAATaaagcaatga
1905378 1905398 [AIBSCS] [41]
  Fur-Fe2+ repressor nacp Sigma54 nd 2061933.0 nac nd nd [GEA] [7]
  Fur-Fe2+ repressor ndhp Sigma70 nd -1166085.0 ndh nd nd [GEA] [7]
  Fur-Fe2+ repressor nohAp Sigma70 2.0 -235.0 nohA, ydfN, tfaQ
acccgtaaagTGATAATGATTATCATCTAcatatcacaa
1636593 1636611 [GEA], [HIBSCS] [10]
  Fur-Fe2+ repressor nohAp Sigma70 4.0 -233.0 nohA, ydfN, tfaQ
ggacccgtaaAGTGATAATGATTATCATCtacatatcac
1636591 1636609 [BPP], [GEA], [HIBSCS] [8], [10]
  Fur-Fe2+ repressor nrdHp Sigma70 -61.0 -128.0 nrdH, nrdI, nrdE, nrdF
catatccaggGTAATTTCGACCACTATTTgctatatatt
2800586 2800604 [AIBSCS], [GEA] [10], [42]
  Fur-Fe2+ activator ompFp Sigma38, Sigma70 nd 986982.0 ompF nd nd [GEA] [17]
  Fur-Fe2+ repressor oppAp Sigma28 -136.0 -233.0 oppA, oppB, oppC, oppD, oppF
ctttattggtAATGAGAATAATTAACAATtaaagagcgt
1300940 1300958 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor purRp Sigma70 -49.0 -204.0 purR
cgtcatttatAATGATAAGTGTTTTTACCacttcccctt
1737631 1737649 [AIBSCS] [14]
  Fur-Fe2+ repressor pyrCp Sigma70 -88.5 -125.0 pyrC
tgattaatcaGTAAATGGAATGACAATTTCGCCTggcttcactt
1122720 1122744 [BPP], [GEA], [HIBSCS] [43]
  Fur-Fe2+ repressor rcnAp Sigma70 78.0 -12.5 rcnA, rcnB
cagattgccgAATTAATACTAAGAATTATTAtcatgaccga
2185894 2185915 [AIBSCS], [GEA], [HIBSCS] [44]
  Fur-Fe2+ repressor rcnAp Sigma70 81.0 -9.5 rcnA, rcnB
attgccgaatTAATACTAAGAATTATTATCAtgaccgaatt
2185897 2185918 [AIBSCS], [GEA] [44]
  Fur-Fe2+ repressor rcnAp Sigma70 87.0 -3.5 rcnA, rcnB
gaattaatacTAAGAATTATTATCATGACCGaatttacaac
2185903 2185924 [AIBSCS], [GEA] [44]
  Fur-Fe2+ repressor rpoSp Sigma70 nd 2867551.0 rpoS nd nd [GEA], [IEP] [7], [38]
  Fur-Fe2+ repressor ryhBp Sigma70 -18.0 -18.0 ryhB
gcgagacaatAATAATCATTCTCATTCGCacttgtccaa
3581025 3581043 [AIBSCS], [GEA], [HIBSCS] [10], [45]
  Fur-Fe2+ repressor ryhBp Sigma70 -15.0 -15.0 ryhB
atcgcgagacAATAATAATCATTCTCATTcgcacttgtc
3581022 3581040 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor ryhBp Sigma70 -12.0 -12.0 ryhB
ctgatcgcgaGACAATAATAATCATTCTCattcgcactt
3581019 3581037 [AIBSCS], [GEA] [10], [45]
  Fur-Fe2+ activator sdhCp Sigma70 -34.0 -253.0 sdhC, sdhD, sdhA, sdhB, sucA, sucB, sucC, sucD
ctatatgtagGTTAATTGTAATGATTTTGtgaacagcct
754915 754933 [AIBSCS], [GEA] [7], [17]
  Fur-Fe2+ repressor sodAp Sigma70 -42.0 -93.0 sodA
ttacgaaaagTACGGCATTGATAATCATTttcaatatca
4100708 4100726 [BCE], [BPP], [GEA], [HIBSCS] [7], [8], [46]
  Fur-Fe2+ repressor sodAp Sigma70 -36.0 -87.0 sodA
aaagtacggcATTGATAATCATTTTCAATatcatttaat
4100714 4100732 [BCE], [BPP], [GEA], [HIBSCS] [7], [8], [46]
  Fur-Fe2+ repressor sodAp Sigma70 -33.0 -84.0 sodA
gtacggcattGATAATCATTTTCAATATCatttaattaa
4100717 4100735 [BCE], [GEA], [HIBSCS] [7], [47]
  Fur-Fe2+ repressor sodAp Sigma70 -30.0 -81.0 sodA
cggcattgatAATCATTTTCAATATCATTtaattaacta
4100720 4100738 [BPP], [GEA], [HIBSCS] [7], [8]
  Fur-Fe2+ repressor soxRp Sigma70 nd -4277469.0 soxR nd nd [GEA] [7]
  Fur-Fe2+ repressor soxSp Sigma70 nd 4277383.0 soxS nd nd [GEA] [7]
  Fur-Fe2+ repressor sufAp Sigma70 -18.0 -50.0 sufA, sufB, sufC, sufD, sufS, sufE
ataacagcatGTTAGTGATAATGATTATCagttcaaccc
1764427 1764445 [BPP], [GEA], [HIBSCS], [SM] [48], [49], [50], [51], [52]
  Fur-Fe2+ activator tonBp Sigma70 -25.0 -60.0 tonB
gtcttgccttATTGAATATGATTGCTATTtgcatttaaa
1311020 1311038 [AIBSCS], [BPP], [HIBSCS] [8], [12], [53]
  Fur-Fe2+ repressor tonBp Sigma70 -19.0 -54.0 tonB
ccttattgaaTATGATTGCTATTTGCATTtaaaatcgag
1311026 1311044 [BCE], [BPP], [HIBSCS] [8], [12], [53]
  Fur-Fe2+ repressor tonBp Sigma70 -15.0 -50.0 tonB
attgaatatgATTGCTATTTGCATTTAAAatcgagacct
1311030 1311048 [BPP], [HIBSCS] [8]
  Fur-Fe2+ repressor tonBp Sigma70 26.0 -10.0 tonB
gtttttctacTGAAATGATTATGACTTCAatgacccttg
1311070 1311088 [BCE] [53]
  Fur-Fe2+ repressor ygaCp nd -5.0 -601.0 ygaC
aatatatagcAAATAGTGGTCGAAATTACcctggatatg
2800586 2800604 [AIBSCS], [GEA] [10], [42]
  Fur-Fe2+ repressor yhhYp Sigma70 -77.0 -104.0 yhhY
ttggacaagtGCGAATGAGAATGATTATTattgtctcgc
3581025 3581043 [AIBSCS], [GEA], [HIBSCS] [10], [45]
  Fur-Fe2+ repressor yjjZp Sigma70 -27.0 -54.0 yjjZ
atttatctggCTTGCAAATGATAAAAATTatcatatgat
4605741 4605759 [AIBSCS], [BPP], [GEA], [HIBSCS] [8], [10], [32]
  Fur-Fe2+ repressor yjjZp Sigma70 3.0 -25.0 yjjZ
atcatatgatATTGGTTATCATTATCAATgaaagagatg
4605770 4605788 [AIBSCS], [BPP], [GEA], [HIBSCS] [8], [10], [32]
  Fur-Fe2+ repressor yqjHp Sigma70 -19.0 -66.0 yqjH
gcaaatgataATGATTGTTAATCATGATAaatgcaagcg
3216548 3216566 [AIBSCS], [GEA], [HIBSCS] [3], [8], [54], [55]
  Fur-Fe2+ repressor yqjHp Sigma70 -15.0 -62.0 yqjH
actcgcaaatGATAATGATTGTTAATCATgataaatgca
3216544 3216562 [AIBSCS], [GEA], [HIBSCS] [3], [8], [55]
  Fur-Fe2+ repressor yqjHp Sigma70 -9.0 -56.0 yqjH
aataaaactcGCAAATGATAATGATTGTTaatcatgata
3216538 3216556 [AIBSCS], [GEA], [HIBSCS] [3], [8], [55]
  Fur-Fe2+ activator zinTp Sigma70 nd -2041375.0 zinT nd nd [GEA] [56]
  Fur-Fe2+ repressor zwfp Sigma70 nd 1936314.0 zwf nd nd [GEA] [7]


Alignment and PSSM for Fur TFBSs    

Position weight matrix (PWM).   
A	44	38	2	8	41	7	39	37	3	4	42	2	8	28	2	5	36	13
C	1	2	5	2	2	0	0	5	9	13	1	6	1	4	10	28	3	9
G	3	3	0	34	1	15	1	0	8	22	5	1	0	3	7	0	5	0
T	0	5	41	4	4	26	8	6	28	9	0	39	39	13	29	15	4	26

PWM logo   


 


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
TF-target gene evolutionary conservation
Promoter-target gene evolutionary conservation


Evidence    

 [IDA] Inferred from direct assay

 [GEA] Gene expression analysis

 [IPI] Inferred from physical interaction

 [BPP] Binding of purified proteins

 [HIBSCS] Human inference based on similarity to consensus sequences

 [BCE] Binding of cellular extracts

 [AIBSCS] Automated inference based on similarity to consensus sequences

 [SM] Site mutation

 [AS] Author statement

 [IMP] Inferred from mutant phenotype

 [IEP] Inferred from expression pattern

 [IGI] Inferred from genetic interaction



Reference(s)    

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 [47] Niederhoffer EC., Naranjo CM., Bradley KL., Fee JA., 1990, Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus., J Bacteriol 172(4):1930-8

 [48] Lee JH., Yeo WS., Roe JH., 2004, Induction of the sufA operon encoding Fe-S assembly proteins by superoxide generators and hydrogen peroxide: involvement of OxyR, IHF and an unidentified oxidant-responsive factor., Mol Microbiol 51(6):1745-55

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