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Synonyms: FlhDC |
Summary:
The FlhD and FlhC proteins are transcriptional factors that form heterohexamers (FlhD4C2) []. The complex transcription factor is the principal regulator of bacterial flagellum biogenesis and swarming migration [1, 3]. This heteromeric regulator activates class II genes involved in the flagellar basal body [1, 2, 3, 5], proteins of the export machinery, the flagellar σ subunit (FliA), and its anti-σ factor, FlgM [1, 3, 11]. Currently, no inducer for this regulator has been reported in the literature. A microarray analysis showed that the master regulator, FlhD4C2, regulates several nonflagellar genes, but the direct effect has not been determined. FlhD and FlhC are part of the unusual flhDC operon that encodes two transcriptional regulators [2]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Connectivity class: | Local Regulator | ||||||||||||
Gene name: | flhC | ||||||||||||
Genome position: | 1977266-1977844 | ||||||||||||
Length: | 579 bp / 192 aa | ||||||||||||
Operon name: | flhDC | ||||||||||||
TU(s) encoding the TF: |
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Gene name: | flhD | ||||||||||||
Genome position: | 1977847-1978197 | ||||||||||||
Length: | 351 bp / 116 aa | ||||||||||||
Operon name: | flhDC | ||||||||||||
TU(s) encoding the TF: |
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Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence![]() |
LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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FlhDC | activator | flgAp | Sigma70 | -68.0 | -90.0 | flgA, flgM, flgN |
tacgcgcgcgTTATCGGCGGAATAAACgcaaaatggg
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1130945 | 1130961 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [3] | |
FlhDC | activator | flgAp | Sigma70 | -40.0 | -62.0 | flgA, flgM, flgN |
caaaatgggtCGCTATTTATGCCGTTGatggtcattg
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1130917 | 1130933 | [APIORCISFBSCS], [CV(GEA)], [GEA] | [3] | |
FlhDC | activator | flgBp | Sigma70 | -67.5 | -93.0 | flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ |
caatgaccatCAACGGCATAAATAGCGacccattttg
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1130917 | 1130933 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [4] | |
FlhDC | activator | flgBp | Sigma70 | -41.5 | -66.5 | flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ |
gacccattttGCGTTTATTCCGCCGATaacgcgcgcg
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1130943 | 1130959 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] | |
FlhDC | activator | flgKp | Sigma28 | nd | nd | flgK, flgL | nd | nd | [BPP], [GEA] | [4] | ||
FlhDC | activator | flhBp | Sigma70 | -67.5 | -92.5 | flhB, flhA, flhE |
atgtgtggcaGCAAAAGCCCTAAATCCCGcctgttttgc
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1966275 | 1966293 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2], [3] | |
FlhDC | activator | flhBp | Sigma70 | -39.0 | -64.0 | flhB, flhA, flhE |
ctgttttgccCCTTACTCAAACCATTGaacgctttgc
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1966247 | 1966263 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2], [3] | |
FlhDC | activator | fliAp1 | Sigma70 | -67.0 | -97.0 | fliA, fliZ, tcyJ |
gaatttacctGTAACCCCCAAATAACCcctcatttca
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2001878 | 2001894 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [2], [3], [4], [5], [6] | |
FlhDC | activator | fliAp1 | Sigma70 | -38.0 | -68.0 | fliA, fliZ, tcyJ |
tcatttcaccCACTAATCGTCCGATTAaaaaccctgc
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2001849 | 2001865 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [2], [3], [4], [5], [6], [7] | |
FlhDC | activator | fliDp | Sigma70 | -69.0 | -124.0 | fliD, fliS, fliT |
cattttttgtTAGTCGCCGAAATACTCttttctctgc
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2003740 | 2003756 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [4] | |
FlhDC | activator | fliDp | Sigma70 | -41.0 | -96.0 | fliD, fliS, fliT |
tttctctgccCCTTATTCCCGCTATTAaaaaaaacaa
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2003768 | 2003784 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [4] | |
FlhDC | activator | fliEp1 | Sigma70 | -69.0 | -91.0 | fliE |
tcgtttttttCTATCCGCCAATAAACCcgtttttttg
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2013097 | 2013113 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [4] | |
FlhDC | activator | fliEp1 | Sigma70 | -40.5 | -62.5 | fliE |
cgtttttttgTTGCTATTTAGCGCCTTTGtcttattgac
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2013068 | 2013086 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [4] | |
FlhDC | activator | fliFp1 | Sigma70 | -69.5 | -152.5 | fliF, fliG, fliH, fliI, fliJ, fliK |
gtcaataagaCAAAGGCGCTAAATAGCAAcaaaaaaacg
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2013068 | 2013086 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [4] | |
FlhDC | activator | fliFp1 | Sigma70 | -41.0 | -124.0 | fliF, fliG, fliH, fliI, fliJ, fliK |
caaaaaaacgGGTTTATTGGCGGATAGaaaaaaacga
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2013097 | 2013113 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3], [4] | |
FlhDC | activator | fliLp1 | Sigma70 | -65.0 | -99.0 | fliL, fliM, fliN, fliO, fliP, fliQ, fliR |
tattttcgccTAACGTCAGAGGTAGCAccgtaatccg
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2019511 | 2019527 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2], [3], [4] | |
FlhDC | activator | fliLp1 | Sigma70 | -37.0 | -71.0 | fliL, fliM, fliN, fliO, fliP, fliQ, fliR |
cgtaatccgcGTCTTTTCCCCGCTTTGttgcgctcaa
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2019539 | 2019555 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [2], [3], [4], [7] | |
FlhDC | activator | glpABCp | Sigma70 | nd | nd | glpA, glpB, glpC | nd | nd | [GEA] | [8] | ||
FlhDC | activator | gltIp1 | Sigma70 | -62.0 | -211.0 | gltI, sroC, gltJ, gltK, gltL |
aatggcgaagAAACGGTCTAAATAGGCtgattcaagg
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687950 | 687966 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] | |
FlhDC | activator | gltIp1 | Sigma70 | -47.5 | -196.5 | gltI, sroC, gltJ, gltK, gltL |
cggtctaaatAGGCTGATTCAAGGCATTTacgggagaaa
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687935 | 687953 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] | |
FlhDC | activator | hydNp | Sigma54 | nd | nd | hydN, hypF | nd | nd | [GEA] | [8] | ||
FlhDC | repressor | mdhp1 | Sigma70 | nd | nd | mdh | nd | nd | [GEA] | [8] | ||
FlhDC | repressor | mglBp | Sigma70, Sigma38 | nd | nd | mglB, mglA, mglC | nd | nd | [GEA] | [8] | ||
FlhDC | activator | napFp1 | Sigma70 | nd | nd | napF, napD, napA, napG, napH, napB, napC, ccmA, ccmB, ccmC, ccmD, ccmE, ccmF, ccmG, ccmH | nd | nd | [GEA] | [8] | ||
FlhDC | activator | napFp2 | Sigma70 | nd | nd | napF, napD, napA, napG, napH, napB, napC, ccmA, ccmB, ccmC, ccmD, ccmE, ccmF, ccmG, ccmH | nd | nd | [GEA] | [8] | ||
FlhDC | activator | nrfAp | Sigma70 | nd | nd | nrfA, nrfB, nrfC, nrfD, nrfE, nrfF, nrfG | nd | nd | [GEA] | [8] | ||
FlhDC | activator | ppdAp | Sigma28 | nd | nd | ppdA, ppdB, ygdB, ppdC, recC | nd | nd | [GEA] | [9] | ||
FlhDC | activator | ycgRp | Sigma28 | nd | nd | ycgR | nd | nd | [GEA] | [10] | ||
FlhDC | activator | yecRp | nd | -68.0 | -90.0 | yecR |
gacacctacaGATGGCAAGAAATAGCGcctgccaggc
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1988124 | 1988140 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] | |
FlhDC | activator | yecRp | nd | -41.0 | -63.0 | yecR |
cctgccaggcGTCTTTTCCGGCCATTGtcgcagcact
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1988151 | 1988167 | [APIORCISFBSCS], [BPP], [CV(GEA)], [CV(GEA)], [GEA] | [3] | |
FlhDC | activator | ygbKp | Sigma28 | nd | nd | ygbK | nd | nd | [GEA] | [9] | ||
FlhDC | activator | yhjHp | Sigma28 | nd | nd | pdeH | nd | nd | [GEA] | [10] |
Alignment and PSSM for FlhDC TFBSs | ![]() |
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Aligned TFBS of FlhDC |
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Sequence | |
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AATAGCGGGAATAAGGGGC | |
AATGGCCGGAAAAGACGCC | |
ACAGGCGGGATTTAGGGCT | |
TATCGGCGGAATAAACGCA | |
AATGGTTTGAGTAAGGGGC | |
AAACGGGTTTATTGGCGGA | |
GATGGCAAGAAATAGCGCC | |
AATAGGCTGATTCAAGGCA | |
AAAGCGGGGAAAAGACGCG | |
AAAGGCGCTAAATAGCAAC | |
AACGGCATAAATAGCGACC | |
TGAGGGGTTATTTGGGGGT | |
AACGGTCTAAATAGGCTGA | |
AATCGGACGATTAGTGGGT | |
TAACGTCAGAGGTAGCACC | |
AAAAGAGTATTTCGGCGAC |
Position weight matrix (PWM). FlhDC matrix-quality result |
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A 12 14 7 3 0 1 3 2 3 14 9 4 8 8 4 0 3 2 4 C 0 1 2 4 1 6 5 2 0 0 0 0 2 0 1 9 0 8 8 G 1 1 0 9 15 6 7 5 10 0 2 1 0 8 10 7 12 6 1 T 3 0 7 0 0 3 1 7 3 2 5 11 6 0 1 0 1 0 3 |
Consensus |
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; consensus.strict aAagGgggGAatagGcGcc ; consensus.strict.rc GGCGCCTATTCCCCCCTTT ; consensus.IUPAC aAwsGsskGAwtwrGsGsc ; consensus.IUPAC.rc GSCSCYWAWTCMSSCSWTT ; consensus.regexp aA[at][cg]G[cg][cg][gt]GA[at]t[at][ag]G[cg]G[cg]c ; consensus.regexp.rc G[CG]C[CG]C[CT][AT]A[AT]TC[AC][CG][CG]C[CG][AT]TT |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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