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RacR DNA-binding transcriptional dual regulator

Synonyms: RacR
RacR is an essential transcriptional repressor for toxin genes ydaS and ydaT, and is thus critical for cell survival; these genes are adjacent to and encode proteins divergent from RacR [1, 2]. RacR's essentiality is based on keeping these toxins transcriptionally silent [1, 2]. RacR comprises a helix-turn-helix (HTH) motif and, based on the genomic context, racR and ydaS cooccur, suggesting a functional interaction between RacR and YdaST [2]. Deletion of the racR gene is lethal [2].

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
RacR Functional   [AIFS], [APPHINH], [IEP], [IHBCE] [1], [2], [3], [4]
Connectivity class: Local Regulator
Gene name: