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Synonyms: CRP-Sxy |
Summary:
CRP appears to interact with the Sxy protein to regulate some genes related to DNA uptake (natural competence). The residues Q194 and L196, located in the named Sxy Interacting Region (SIR) and close to the DNA-binding region in CRP, appear to be involved in the CRP-Sxy interaction [2]. The CRP-Sxy complex recognized a DNA-binding site that has an asymmetric organization: it has two distinct half sites, one of which is similar to the canonical CRP DNA-binding site, but the other half site is less conserved [2]. In E. coli [3] and in some other bacteria, the putative regulon CRP-Sxy has been identified through microarray analysis [4, 5]. |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Connectivity class: | Local Regulator | ||||||||||||||
Gene name: | crp | ||||||||||||||
Genome position: | 3486120-3486752 | ||||||||||||||
Length: | 633 bp / 210 aa | ||||||||||||||
Operon name: | crp | ||||||||||||||
TU(s) encoding the TF: |
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Gene name: | sxy | ||||||||||||||
Genome position: | 1021138-1021767 | ||||||||||||||
Length: | 630 bp / 209 aa | ||||||||||||||
Operon name: | sxy | ||||||||||||||
TU(s) encoding the TF: |
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Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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CRP-Sxy | activator | sxyp | Sigma70 | -81.5 | -136.5 | sxy |
tcaaccctatTTTCGGAAAGAGCCTCGCAAATTttgtcgttgg
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1020991 | 1021013 | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [COMP-HINF-SIMILAR-TO-CONSENSUS] | W | [1], [2] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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