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YcjW DNA-binding transcriptional dual regulator

Synonyms: YcjW
Summary:
YcjW is a transcriptional regulator involved in the control of carbohydrate metabolism genes [4]. ycjW was identified in a screen for genes that reduce the lethal effects of stress. A ycjW insertion mutant is more sensitive than wild type to mitomycin C [5].


Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
YcjW Functional   [HIFS] [1], [2], [3]
Evolutionary Family: GalR/LacI
Connectivity class: Local Regulator
Gene name: ycjW
  Genome position: 1382963-1383961
  Length: 999 bp / 332 aa
Operon name: ycjW
TU(s) encoding the TF:
Transcription unit        Promoter
ycjW
 


Regulon       
Regulated gene(s)
Regulated operon(s)
First gene in the operon(s)
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References



High-throughput Transcription factor binding sites (TFBSs)
      

  Functional conformation Function Object name Object type Distance to first Gene Sequence LeftPos RightPos Growth Condition Evidence (Confirmed, Strong, Weak) References
  YcjW repressor nd nd nd 1370190 1370203 nd [BPP], [GEA] [4]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation


Evidence    


Reference(s)    

 [1] Paradis-Bleau C., Kritikos G., Orlova K., Typas A., Bernhardt TG., 2014, A genome-wide screen for bacterial envelope biogenesis mutants identifies a novel factor involved in cell wall precursor metabolism., PLoS Genet 10(1):e1004056

 [2] Perez-Rueda E., Collado-Vides J., 2000, The repertoire of DNA-binding transcriptional regulators in Escherichia coli K-12., Nucleic Acids Res 28(8):1838-47

 [3] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50

 [4] Luhachack L., Rasouly A., Shamovsky I., Nudler E., 2019, Transcription factor YcjW controls the emergency H2 S production in E. coli., Nat Commun 10(1):2868

 [5] Han X., Dorsey-Oresto A., Malik M., Wang JY., Drlica K., Zhao X., Lu T., 2010, Escherichia coli genes that reduce the lethal effects of stress., BMC Microbiol 10:35



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