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Synonyms: UhpA, UhpA-Pasp |
Summary:
The regulatory protein for "uptake of hexose phosphates," UhpA [], activates the transcription of a gene that codes for UhpT, a protein that transports many phosphorylated sugars into the cell []. UhpA is the response regulator in the unusual two-component regulatory system comprised of three proteins, UhpA/UhpB/UhpC, and is a member of the NarL subfamily of response regulators. The signal that triggers this signaling pathway is glucose 6-phosphate external. This sugar is sensed by UhpC, which interacts with UhpB to stimulate its autophosphorylation. Then, phosphorylated UhpB transfers the phosphate group to UhpA in Asp-54 to activate it [13]. UhpB unphosphorylated is able to dephosphorylate to UhpA [13, 14]. UhpA has two modules: the receiver module, which contains the putative site of phosphorylation in the N-terminal domain [5], and the activation module, which contains a helix-turn-helix motif for DNA binding in the C-terminal domain[5, 15]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | LuxR/UhpA | ||||||||||||||||||
Sensing class: | External-Two-component systems | ||||||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | uhpA | ||||||||||||||||||
Genome position: | 3850136-3850726 | ||||||||||||||||||
Length: | 591 bp / 196 aa | ||||||||||||||||||
Operon name: | ivbL-ilvBN-uhpABC | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | uhpT | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (1)
Porters (Uni-, Sym- and Antiporters) (1)
membrane (1)
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Regulated operon(s) | uhpT | ||||||
First gene in the operon(s) | uhpT | ||||||
Simple and complex regulons | CRP,UhpA,UvrY | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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UhpA-Pasp | activator | uhpTp | Sigma70 | -64.5 | -95.5 | uhpT |
tatccggcaaAACTAAGAAATTTTCCAGGTtttgcctgga
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3847253 | 3847272 | [BPP], [CV(SM)], [GEA], [SM] | [1], [2], [3], [6], [7], [8] | |
UhpA-Pasp | activator | uhpTp | Sigma70 | -41.5 | -72.5 | uhpT |
tccaggttttGCCTGGACGCTATCTCAGGCctgatttgct
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3847230 | 3847249 | [BCE], [BPP], [CV(GEA)], [CV(GEA)], [CV(GEA/SM)], [CV(SM)], [GEA], [SM] | [1], [2], [3], [6], [7], [8], [9], [10], [11], [12] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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