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Synonyms: FrlR-N6-(6-phospho-D-fructosyl)-L-lysine, FlrR |
Summary:
As a dimer, FrlR binds DNA to regulate transcription, and it becomes inactive as a regulator when it is bound to fructoselysine-6-phosphate [1] It has a winged helix-turn-helix domain for binding DNA, and this domain contains the amino acids Arg49, Gly70, and Lys71, which appear to be essential for DNA binding [1] FrlR has similarity to Bacillus subtilis FrlR [1, 2], B. subtilis NagR [1] and S. enterica FraR [1] As homologues, this protein appears to pertain to the GntR/HutC family of transcriptional regulators [1] FrlR: fructolysine [2]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Connectivity class: | Local Regulator | ||||||||||||||||||
Gene name: | frlR | ||||||||||||||||||
Genome position: | 3504052-3504783 | ||||||||||||||||||
Length: | 732 bp / 243 aa | ||||||||||||||||||
Operon name: | frlABCDR | ||||||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | frlA, frlB, frlC, frlD, frlR | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (3)
Porters (Uni-, Sym- and Antiporters) (1)
membrane (1)
Transcription related (1)
repressor (1)
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Regulated operon(s) | frlABCDR | ||||||
First gene in the operon(s) | frlA | ||||||
Simple and complex regulons | CRP,FrlR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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FlrR | repressor | frlAp1 | Sigma70 | 12.5 | -63.5 | frlA, frlB, frlC, frlD, frlR |
atcatgcattGTCATGTTACcttttaaatg
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3499842 | 3499851 | [GEA], [APIORCISFBSCS], [BPP], [SM] | [1] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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