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AaeR DNA-binding transcriptional activator

Synonyms: AaeR
Summary:
Based on Genomic SELEX screening it was suggested that AaeR could regulate genes involved in biofilm formation and genes encoding several TFs, such as NimR, Rob, SlyA, YcaN, YgaV, and YneJ [1]. However, in the presence of some hydroxylated and nonhydroxylated aromatic carboxylic acids, such asp-hyroxybenzoic acid (pHBA), salicylate, benzoate, and 1-naphthoate, AaeR binds an intergenic region of its own gene (aaeR) and the aaeXAB operon to activate this operon [1, 2]. AaeR mutants have been shown to require alternative expression of AaeA and AaeB to reverse the resulting pHBA sensitivity [2]. AaeR is a member of the LysR family of transcriptional regulators [3]. AaeR is thought to be a virulence regulator that is activated by quorum sensing, and to be involved in activation of expression of LEE (locus of enterocyte effacement) pathogenicity genes in enterohemorrhagic and enteropathogenic E. coli. In virulent E.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
AaeR Functional   nd nd nd
TFBs symmetry: inverted-repeat
Connectivity class: Local Regulator
Gene name: aaeR
  Genome position: 3389520-3390449
  Length: 930 bp / 309 aa
Operon name: aaeR
TU(s) encoding the TF:
Transcription unit        Promoter
aaeR
aaeRp


Regulon       
Regulated gene(s) aaeA, aaeB, aaeX
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
transport (2)
membrane (2)
Regulated operon(s) aaeXAB
First gene in the operon(s) aaeX
Simple and complex regulons AaeR,CRP
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[AaeR,+](1)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  AaeR activator aaeXp nd nd nd aaeX, aaeA, aaeB nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-GSELEX] W [1]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation






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