RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,PhoB,RcdA,RstA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PhoB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator PhoB, PhoB response regulator, PhoT
Gene name(s): phoB
Functional conformation(s): PhoB-Phosphorylated , PhoB
Coregulator(s): ArgP, AscG, CRP, CpxR, CusR, EnvY, FNR, Fur, GadE, GadW, GadX, H-NS, HprR, IHF, Nac, NsrR, OmpR, PhoB, PrpR, QseB, RcdA, RstA, RutR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RstA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional regulator RstA, RstA response regulator, UrpT
Gene name(s): rstA
Functional conformation(s): RstA , RstA-Phosphorylated
Coregulator(s): BasR, CRP, CpxR, Cra, CsgD, EnvY, FNR, Fis, FliZ, Fur, H-NS, IHF, MlrA, MqsA, NarL, OmpR, PhoB, RcdA, RcsB, RstA, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RcdA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional regulator RcdA, YbjK
Gene name(s): rcdA
Functional conformation(s): RcdA
Coregulator(s): ArcA, BasR, CRP, CpxR, Cra, CsgD, FliZ, H-NS, IHF, LexA, McbR, MlrA, MqsA, OmpR, PhoB, RcdA, RcsB, RstA, SdiA, SlyA, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,PhoB,RcdA,RstA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor PhoB activator RcdA activator RstA activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
PhoB-Phosphorylated activator asrp asr 1671288 1671306 -30.0 aaaccaaccaCTCACGGAAGTCTGCCATTcccagggata [BCE]
[GEA]
[HIBSCS]
[1]
RstA-Phosphorylated activator asrp asr 1671257 1671273 -62.0 attcagcgttTGTACATATCGTTACACgctgaaacca [BPP]
[GEA]
[HIBSCS]
[2]
RcdA activator asrp asr 1671264 1671274 -58.5 gtttgtacatATCGTTACACGctgaaaccaa [BPP]
[GEA]
[IC]
[3]
RcdA activator asrp asr 1671254 1671264 -68.5 tttattcagcGTTTGTACATAtcgttacacg [BPP]
[GEA]
[IC]
[3]
H-NS repressor asrp asr         [GEA]
[IMP]
[4]

Evidence: [BCE] Binding of cellular extracts
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[IC] Inferred by curator
[IMP] Inferred from mutant phenotype
Reference(s): [1] Suziedeliene E., et al., 1999
[2] Ogasawara H., et al., 2007
[3] Shimada T., et al., 2012
[4] Seputiene V., et al., 2004



Reference(s)    

 [1] Suziedeliene E., Suziedelis K., Garbenciete V., Normark S., 1999, The acid-inducible asr gene in Escherichia coli: transcriptional control by the phoBR operon., J Bacteriol 181(7):2084-93

 [2] Ogasawara H., Hasegawa A., Kanda E., Miki T., Yamamoto K., Ishihama A., 2007, Genomic SELEX search for target promoters under the control of the PhoQP-RstBA signal relay cascade., J Bacteriol 189(13):4791-9

 [3] Shimada T., Katayama Y., Kawakita S., Ogasawara H., Nakano M., Yamamoto K., Ishihama A., 2012, A novel regulator RcdA of the csgD gene encoding the master regulator of biofilm formation in Escherichia coli., Microbiologyopen 1(4):381-94

 [4] Seputiene V., Suziedelis K., Normark S., Melefors O., Suziedeliene E., 2004, Transcriptional analysis of the acid-inducible asr gene in enterobacteria., Res Microbiol 155(7):535-42


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