RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
H-NS activator cmoMp cmoM , mukF , mukE , mukB         [GEA] [1]
H-NS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
H-NS repressor yjjPp yjjP 4603204 4603214 -174.5 agaaatcacaTTCATTTAATTtataattaaa [BPP] [2]
H-NS repressor yjjPp yjjP 4603191 4603201 -161.5 atttaatttaTAATTAAATGAtatcccttcc [BPP] [2]
H-NS repressor hdfRp hdfR         [BPP] [3]
H-NS repressor hchAp2 hchA         [BPP]
[GEA]
[4]
H-NS repressor adiYp adiY         [BPP] [3]
H-NS repressor mdtJp mdtI , mdtJ 1673487 1673497 288.5 aggacaatgtATATTTATTGGattttattag [AIBSCS]
[BPP]
[GEA]
[5]
H-NS repressor ydeOp ydeO         [BPP] [3]
H-NS repressor mdtJp mdtI , mdtJ 1673535 1673545 240.5 tggtttcgctGAATTAAGCGAaaattaaaat [AIBSCS]
[BPP]
[GEA]
[5]
H-NS repressor mdtJp mdtI , mdtJ 1673785 1673795 -10.5 attcttaagcTATGATACAAAtcaggcgtgt [AIBSCS]
[BPP]
[GEA]
[5]
H-NS repressor rcsDp rcsD , rcsB         [BPP] [3]
H-NS repressor proVp1 proV , proW , proX         [BPP]
[GEA]
[6]
[7]
H-NS repressor chiAp chiA         [BPP]
[GEA]
[8]
H-NS repressor fimBp1 fimB         [BPP]
[GEA]
[9]
[10]
[11]
H-NS repressor gspAp1 gspB , gspA         [BPP]
[GEA]
[12]
H-NS repressor gspAp2 gspB , gspA         [BPP]
[GEA]
[12]
H-NS repressor hchAp hchA         [BPP]
[GEA]
[4]
H-NS repressor adep adeD         [GEA] [13]

Evidence: [GEA] Gene expression analysis
[BPP] Binding of purified proteins
[AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Yamanaka K., et al., 1995
[2] Stratmann T., et al., 2008
[3] Krin E., et al., 2010
[4] Mujacic M., et al., 2006
[5] Leuzzi A., et al., 2015
[6] Lucht JM., et al., 1994
[7] Rajkumari K., et al., 2001
[8] Francetic O., et al., 2000
[9] Donato GM., et al., 1999
[10] Donato GM., et al., 1997
[11] Olsen PB., et al., 1998
[12] Francetic O., et al., 2000
[13] Petersen C., et al., 2002



Reference(s)    

 [1] Yamanaka K., Ogura T., Niki H., Hiraga S., 1995, Characterization of the smtA gene encoding an S-adenosylmethionine-dependent methyltransferase of Escherichia coli., FEMS Microbiol Lett 133(1-2):59-63

 [2] Stratmann T., Madhusudan S., Schnetz K., 2008, Regulation of the yjjQ-bglJ operon, encoding LuxR-type transcription factors, and the divergent yjjP gene by H-NS and LeuO., J Bacteriol 190(3):926-35

 [3] Krin E., Danchin A., Soutourina O., 2010, Decrypting the H-NS-dependent regulatory cascade of acid stress resistance in Escherichia coli., BMC Microbiol 10:273

 [4] Mujacic M., Baneyx F., 2006, Regulation of Escherichia coli hchA, a stress-inducible gene encoding molecular chaperone Hsp31., Mol Microbiol 60(6):1576-89

 [5] Leuzzi A., Di Martino ML., Campilongo R., Falconi M., Barbagallo M., Marcocci L., Pietrangeli P., Casalino M., Grossi M., Micheli G., Colonna B., Prosseda G., 2015, Multifactor Regulation of the MdtJI Polyamine Transporter in Shigella., PLoS One 10(8):e0136744

 [6] Lucht JM., Dersch P., Kempf B., Bremer E., 1994, Interactions of the nucleoid-associated DNA-binding protein H-NS with the regulatory region of the osmotically controlled proU operon of Escherichia coli., J Biol Chem 269(9):6578-8

 [7] Rajkumari K., Gowrishankar J., 2001, In vivo expression from the RpoS-dependent P1 promoter of the osmotically regulated proU operon in Escherichia coli and Salmonella enterica serovar Typhimurium: activation by rho and hns mutations and by cold stress., J Bacteriol 183(22):6543-50

 [8] Francetic O., Badaut C., Rimsky S., Pugsley AP., 2000, The ChiA (YheB) protein of Escherichia coli K-12 is an endochitinase whose gene is negatively controlled by the nucleoid-structuring protein H-NS., Mol Microbiol 35(6):1506-17

 [9] Donato GM., Kawula TH., 1999, Phenotypic analysis of random hns mutations differentiate DNA-binding activity from properties of fimA promoter inversion modulation and bacterial motility., J Bacteriol 181(3):941-8

 [10] Donato GM., Lelivelt MJ., Kawula TH., 1997, Promoter-specific repression of fimB expression by the Escherichia coli nucleoid-associated protein H-NS., J Bacteriol 179(21):6618-25

 [11] Olsen PB., Schembri MA., Gally DL., Klemm P., 1998, Differential temperature modulation by H-NS of the fimB and fimE recombinase genes which control the orientation of the type 1 fimbrial phase switch., FEMS Microbiol Lett 162(1):17-23

 [12] Francetic O., Belin D., Badaut C., Pugsley AP., 2000, Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion., EMBO J 19(24):6697-703

 [13] Petersen C., Moller LB., Valentin-Hansen P., 2002, The cryptic adenine deaminase gene of Escherichia coli. Silencing by the nucleoid-associated DNA-binding protein, H-NS, and activation by insertion elements., J Biol Chem 277(35):31373-80


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