RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,Cra,PrpR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Cra Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator Cra, FruC, FruR, Shl
Gene name(s): cra
Functional conformation(s): Cra , Cra-β-D-fructofuranose 1-phosphate , Cra-β-D-fructose 1,6-bisphosphate
Coregulator(s): AcrR, ArcA, BasR, BetI, CRP, CpxR, Cra, CsgD, CusR, DksA, FNR, Fis, FliZ, Fur, GadE, GlcC, GntR, H-NS, HprR, IHF, IclR, KdgR, Lrp, MarA, MarR, Mlc, MlrA, MqsA, NagC, NarL, NarP, OmpR, PdhR, PrpR, RcdA, RcsB, Rob, RstA, SgrR, SoxS, TyrR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
PrpR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator PrpR, YahP
Gene name(s): prpR
Functional conformation(s): PrpR-(2S,3S)-2-methylcitrate
Coregulator(s): AscG, CRP, Cra, PhoB, PrpR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,Cra,PrpR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator Cra repressor PrpR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
PrpR-(2S,3S)-2-methylcitrate activator prpBp prpB , prpC , prpD , prpE 348487 348510 -147.5 gtttagtcttGTTTCATAATTGTTGCAATGAAACgcggtgaaac [GEA]
[HIBSCS]
[1]
CRP-cAMP activator prpBp prpB , prpC , prpD , prpE 348529 348551 -106.5 acattgcctgAAACGTTAACTGAAACGCATATTtgcggattag [BPP]
[GEA]
[HIBSCS]
[SM]
[2]
[1]
Cra repressor prpBp prpB , prpC , prpD , prpE 348536 348553 -101.5 ctgaaacgttAACTGAAACGCATATTTGcggattagtt [AIBSCS]
[GEA]
[3]
PrpR-(2S,3S)-2-methylcitrate activator prpBp prpB , prpC , prpD , prpE 348521 348544 -113.5 gcggtgaaacATTGCCTGAAACGTTAACTGAAACgcatatttgc [HIBSCS] [1]

Evidence: [GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[SM] Site mutation
[AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Lee SK., et al., 2005
[2] Ishida Y., et al., 2009
[3] Shimada T., et al., 2011



Reference(s)    

 [1] Lee SK., Newman JD., Keasling JD., 2005, Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein., J Bacteriol 187(8):2793-800

 [2] Ishida Y., Kori A., Ishihama A., 2009, Participation of regulator AscG of the beta-glucoside utilization operon in regulation of the propionate catabolism operon., J Bacteriol 191(19):6136-44

 [3] Shimada T., Yamamoto K., Ishihama A., 2011, Novel Members of the Cra Regulon Involved in Carbon Metabolism in Escherichia coli., J Bacteriol 193(3):649-59


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