RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


OxyR,Zur regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
OxyR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator OxyR, MomR, Mor, bifunctional regulatory protein sensor for oxidative stress
Gene name(s): oxyR
Functional conformation(s): OxyR
Coregulator(s): CRP, ExuR, FNR, Fis, Fur, H-NS, IHF, IscR, MarA, MetJ, MetR, MntR, NarL, NarP, NsrR, OxyR, Rob, SoxS, UxuR, Zur
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Zur      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor Zur, YjbK, ZnuR
Gene name(s): zur
Functional conformation(s): Zur , Zur-Zn2+
Coregulator(s): Fur, OxyR, SoxS, Zur
Summary: TF Summary ...[more]

REGULATION EXERTED BY OxyR,Zur Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
OxyR activator Zur repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Zur-Zn2+ repressor znuCp znuC , znuB 1942613 1942636 -10.0 atgaatatgaGAAGTGTGATATTATAACATTTCAtgactactgc [BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
Zur-Zn2+ repressor znuAp znuA 1942613 1942636 38.0 gcagtagtcaTGAAATGTTATAATATCACACTTCtcatattcat [BPP]
[GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
OxyR activator znuAp znuA 1942598 1942614 55.5 atatcacactTCTCATATTCATTACGAttattggtcg [CEUMA]
[IHBCE]
[RE]
[5]
OxyR activator znuCp znuC , znuB 1942598 1942614 -27.5 cgaccaataaTCGTAATGAATATGAGAagtgtgatat [CEUMA]
[IHBCE]
[RE]
[5]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[CEUMA] ChIP-exo evidence used in manual assertion
[IHBCE] Inferred by a human based on computational evidence
[RE] RNA-seq evidence
Reference(s): [1] Outten CE., et al., 2001
[2] Patzer SI., et al., 2000
[3] Patzer SI., et al., 1998
[4] Warner DM., et al., 2012
[5] Seo SW., et al., 2015



Reference(s)    

 [1] Outten CE., O'Halloran TV., 2001, Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis., Science 292(5526):2488-92

 [2] Patzer SI., Hantke K., 2000, The zinc-responsive regulator Zur and its control of the znu gene cluster encoding the ZnuABC zinc uptake system in Escherichia coli., J Biol Chem 275(32):24321-32

 [3] Patzer SI., Hantke K., 1998, The ZnuABC high-affinity zinc uptake system and its regulator Zur in Escherichia coli., Mol Microbiol 28(6):1199-210

 [4] Warner DM., Levy SB., 2012, SoxS increases the expression of the zinc uptake system ZnuACB in an Escherichia coli murine pyelonephritis model., J Bacteriol 194(5):1177-85

 [5] Seo SW., Kim D., Szubin R., Palsson BO., 2015, Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655., Cell Rep 12(8):1289-99


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