RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


FNR,H-NS,NrdR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
FNR Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA
Gene name(s): fnr
Functional conformation(s): FNR , FNR-[2Fe-2S]2+ oxidized
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NrdR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): NrdR transcriptional repressor, YbaD
Gene name(s): nrdR
Functional conformation(s): NrdR-Zn2+ , NrdR-dATP , NrdR-ATP
Coregulator(s): ArgP, CRP, DnaA, FNR, Fis, Fur, H-NS, IscR, NrdR
Summary: TF Summary ...[more]

REGULATION EXERTED BY FNR,H-NS,NrdR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
FNR activator H-NS repressor NrdR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
FNR activator nrdDp nrdG , nrdD 4462865 4462878 -33.5 tcaaacatccTTGATGCAAAGCACtatatataga [BPP]
[GEA]
[HIBSCS]
[SM]
[1]
[2]
FNR activator nrdDp nrdG , nrdD 4462896 4462909 -64.5 gctttttactTTGAGCTACATCAAaaaaagctca [BPP]
[GEA]
[HIBSCS]
[SM]
[1]
[2]
NrdR-Zn2+ repressor nrdDp nrdG , nrdD 4462853 4462868 -22.5 ttgatgcaaaGCACTATATATAGACTttaaaatgcg [BPP]
[GEA]
[HIBSCS]
[3]
NrdR-Zn2+ repressor nrdDp nrdG , nrdD 4462822 4462837 9.5 atgcgtcccaACCCAATATGTTGTATtaatcgacta [BPP]
[GEA]
[HIBSCS]
[3]
H-NS repressor nrdDp nrdG , nrdD         [BPP]
[GEA]
[4]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[SM] Site mutation
Reference(s): [1] Boston T., et al., 2003
[2] Roca I., et al., 2008
[3] Torrents E., et al., 2007
[4] Cendra Mdel M., et al., 2013



Reference(s)    

 [1] Boston T., Atlung T., 2003, FNR-mediated oxygen-responsive regulation of the nrdDG operon of Escherichia coli., J Bacteriol 185(17):5310-3

 [2] Roca I., Ballana E., Panosa A., Torrents E., Gibert I., 2008, Fumarate and nitrate reduction (FNR) dependent activation of the Escherichia coli anaerobic ribonucleotide reductase nrdDG promoter., Int Microbiol 11(1):49-56

 [3] Torrents E., Grinberg I., Gorovitz-Harris B., Lundstrom H., Borovok I., Aharonowitz Y., Sjoberg BM., Cohen G., 2007, NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes., J Bacteriol 189(14):5012-21

 [4] Cendra Mdel M., Juarez A., Madrid C., Torrents E., 2013, H-NS is a novel transcriptional modulator of the ribonucleotide reductase genes in Escherichia coli., J Bacteriol 195(18):4255-63


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