RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,GalR,GalS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalS Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalS, MglD
Gene name(s): galS
Functional conformation(s): GalS-D-galactose , GalS
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalR
Gene name(s): galR
Functional conformation(s): GalR , GalR-D-galactose
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,GalR,GalS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator GalR repressor GalS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator galSp galS 2241742 2241763 -42.5 ccgtttccatTGCTGTGACTCGATTCACGAAGtcctgtattc [AIBSCS]
[BCE]
[GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
GalR repressor galSp galS 2241612 2241627 91.5 ctggcgtctcTGTGGCAACGGTTTCCcgggtgctca [GEA]
[HIBSCS]
[1]
[2]
[3]
GalS repressor galSp galS 2241764 2241779 -61.5 aacaaaacggCTGTAACCGTTTCCATtgctgtgact [BCE]
[GEA]
[1]
[3]
GalS repressor galSp galS 2241611 2241626 92.5 tggcgtctctGTGGCAACGGTTTCCCgggtgctcaa [BCE]
[GEA]
[1]
[3]
GalR repressor galSp galS 2241764 2241779 -61.5 aacaaaacggCTGTAACCGTTTCCATtgctgtgact [GEA]
[HIBSCS]
[2]
[3]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[BCE] Binding of cellular extracts
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Semsey S., et al., 2007
[2] Weickert MJ., et al., 1993
[3] Weickert MJ., et al., 1993
[4] Zheng D., et al., 2004



Reference(s)    

 [1] Semsey S., Krishna S., Sneppen K., Adhya S., 2007, Signal integration in the galactose network of Escherichia coli., Mol Microbiol 65(2):465-76

 [2] Weickert MJ., Adhya S., 1993, The galactose regulon of Escherichia coli., Mol Microbiol 10(2):245-51

 [3] Weickert MJ., Adhya S., 1993, Control of transcription of gal repressor and isorepressor genes in Escherichia coli., J Bacteriol 175(1):251-8

 [4] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93


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