RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


IlvY regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
IlvY      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator IlvY, positive regulator for ilvC
Gene name(s): ilvY
Functional conformation(s): IlvY , IlvY-Alfa-acetohydroxybutirate , IlvY-(S)-2-acetolactate
Coregulator(s): IlvY
Summary: TF Summary ...[more]

REGULATION EXERTED BY IlvY Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
IlvY repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IlvY repressor ilvYp ilvY 3957874 3957891 -15.0 acaggaaattTATTGCGGAAATTGATATattcacaacg [BCE]
[BPP]
[GEA]
[HIBSCS]
[IC]
[1]
[2]
IlvY repressor ilvYp ilvY 3957843 3957860 17.0 cacaacgtcaCATTGCAATTTTTGCAACgtcaacatcg [BCE]
[BPP]
[GEA]
[HIBSCS]
[IC]
[3]
[4]
[1]
[5]
[2]
IlvY activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IlvY-(S)-2-acetolactate activator ilvCp ilvC 3957843 3957860 -61.0 cgatgttgacGTTGCAAAAATTGCAATGtgacgttgtg [BCE]
[BPP]
[GEA]
[HIBSCS]
[IC]
[3]
[4]
[1]
[5]
[2]
IlvY-(S)-2-acetolactate activator ilvCp ilvC 3957874 3957891 -30.0 cgttgtgaatATATCAATTTCCGCAATAaatttcctgt [BCE]
[BPP]
[GEA]
[HIBSCS]
[IC]
[1]
[2]

Evidence: [BCE] Binding of cellular extracts
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[IC] Inferred by curator
Reference(s): [1] Rhee KY., et al., 1998
[2] Wek RC., et al., 1988
[3] Biel AJ., et al., 1981
[4] Pledger WJ., et al., 1973
[5] Watson MD., et al., 1979



Reference(s)    

 [1] Rhee KY., Senear DF., Hatfield GW., 1998, Activation of gene expression by a ligand-induced conformational change of a protein-DNA complex., J Biol Chem 273(18):11257-66

 [2] Wek RC., Hatfield GW., 1988, Transcriptional activation at adjacent operators in the divergent-overlapping ilvY and ilvC promoters of Escherichia coli., J Mol Biol 203(3):643-63

 [3] Biel AJ., Umbarger HE., 1981, Mutations in the ilvY gene of Escherichia coli K-12 that cause constitutive expression of ilvC., J Bacteriol 146(2):718-24

 [4] Pledger WJ., Umbarger HE., 1973, Isoleucine and valine metabolism in Escherichia coli. XXII. A pleiotropic mutation affecting induction of isomeroreductase activity., J Bacteriol 114(1):195-207

 [5] Watson MD., Wild J., Umbarger HE., 1979, Positive control of ilvC expression in Escherichia coli K-12; identification and mapping of regulatory gene ilvY., J Bacteriol 139(3):1014-20


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