RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


ArcA,BetI,Cra regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArcA Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class External-Two-component systems
Synonym(s): ArcA response regulator, CpxC, DNA-binding transcriptional dual regulator ArcA, Dye, FexA, Msp, Seg, SfrA, dye resistance protein
Gene name(s): arcA
Functional conformation(s): ArcA-Phosphorylated , ArcA
Coregulator(s): AdiY, AppY, ArcA, BetI, CRP, CadC, CaiF, Cra, CusR, CysB, DcuR, DksA-ppGpp, DnaA, DpiA, FNR, FadR, Fis, FlhDC, Fur, GadE, GadW, GadX, GatR, GlcC, GlpR, H-NS, HipB, HprR, HypT, IHF, IclR, IscR, LexA, LldR, Lrp, MarA, McbR, Mlc, ModE, MqsA, NarL, NarP, NsrR, NtrC, OmpR, PdhR, PhoP, PuuR, RcdA, RcsB, RhaS, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, TreR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
BetI      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional repressor BetI
Gene name(s): betI
Functional conformation(s): BetI-choline , BetI
Coregulator(s): ArcA, BetI, Cra
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Cra Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator Cra, FruC, FruR, Shl
Gene name(s): cra
Functional conformation(s): Cra , Cra-β-D-fructofuranose 1-phosphate , Cra-β-D-fructose 1,6-bisphosphate
Coregulator(s): AcrR, ArcA, BasR, BetI, CRP, CpxR, Cra, CsgD, CusR, DksA, FNR, Fis, FliZ, Fur, GadE, GlcC, GntR, H-NS, HprR, IHF, IclR, KdgR, Lrp, MarA, MarR, Mlc, MlrA, MqsA, NagC, NarL, NarP, OmpR, PdhR, PrpR, RcdA, RcsB, Rob, RstA, SgrR, SoxS, TyrR, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArcA,BetI,Cra Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArcA repressor BetI repressor Cra activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArcA-Phosphorylated repressor betIp betA , betB , betI 329360 329374 -6.0 tcaataaccgCTTTAATAGATAAACaccgctgatg [BCE] [1]
[2]
BetI repressor betIp betA , betB , betI 329381 329400 -30.0 agacacatttTATATTGAACGTCCAATCAAtaaccgcttt [BPP]
[GEA]
[GS]
[HIBSCS]
[1]
[3]
[4]
ArcA-Phosphorylated repressor betIp betA , betB , betI 329428 329442 -74.0 cactgttattGTTACTATTTAAAATcaaattcgta [BCE]
[GEA]
[1]
ArcA-Phosphorylated repressor betTp betT 329428 329442 15.0 tacgaatttgATTTTAAATAGTAACaataacagtg [BCE]
[GEA]
[1]
BetI repressor betTp betT 329381 329400 -30.0 aaagcggttaTTGATTGGACGTTCAATATAaaatgtgtct [BPP]
[GEA]
[GS]
[HIBSCS]
[1]
[3]
[4]
ArcA-Phosphorylated repressor betTp betT 329416 329430 3.0 tgtcttaattGTTACGAATTTGATTttaaatagta [BCE]
[GEA]
[1]
[2]
Cra activator betTp betT         [GEA] [5]
Cra activator betIp betA , betB , betI         [GEA] [5]

Evidence: [BCE] Binding of cellular extracts
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[GS] genomic SELEX
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Lamark T., et al., 1996
[2] Lynch AS., et al., 1996
[3] Rkenes TP., et al., 1996
[4] Shimada T., et al., 2018
[5] Son YJ., et al., 2011



Reference(s)    

 [1] Lamark T., Rokenes TP., McDougall J., Strom AR., 1996, The complex bet promoters of Escherichia coli: regulation by oxygen (ArcA), choline (BetI), and osmotic stress., J Bacteriol 178(6):1655-62

 [2] Lynch AS., Lin EC., 1996, Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters., J Bacteriol 178(21):6238-49

 [3] Rkenes TP., Lamark T., Strom AR., 1996, DNA-binding properties of the BetI repressor protein of Escherichia coli: the inducer choline stimulates BetI-DNA complex formation., J Bacteriol 178(6):1663-70

 [4] Shimada T., Ogasawara H., Ishihama A., 2018, Single-target regulators form a minor group of transcription factors in Escherichia coli K-12., Nucleic Acids Res 46(8):3921-3936

 [5] Son YJ., Phue JN., Trinh LB., Lee SJ., Shiloach J., 2011, The role of Cra in regulating acetate excretion and osmotic tolerance in E. coli K-12 and E. coli B at high density growth., Microb Cell Fact 10:52


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