RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CspA,Fis,GadX,H-NS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GadX Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator GadX, YhiX
Gene name(s): gadX
Functional conformation(s): GadX
Coregulator(s): AdiY, AraC, ArcA, CRP, CadC, CspA, EvgA, FNR, Fis, FliZ, Fur, GadE, GadW, GadX, H-NS, Lrp, MarA, MqsA, NagC, NtrC, OmpR, PhoB, PhoP, RcsB, RutR, SdiA, TorR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CspA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): CS7.4, DNA-binding transcriptional activator CspA, F10.6, cold shock protein CspA, major cold shock protein 7.4
Gene name(s): cspA
Functional conformation(s): CspA
Coregulator(s): CRP, CspA, Fis, GadX, H-NS
Summary: TF Summary ...[more]

REGULATION EXERTED BY CspA,Fis,GadX,H-NS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CspA activator Fis activator GadX activator H-NS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
H-NS repressor hnsp hns 1293133 1293147 -182.0 cccataaaatGTGACATGAATCAGGaagttttaac [BPP]
[GEA]
[1]
[2]
[3]
[4]
H-NS repressor hnsp hns 1293064 1293078 -113.0 ctatatgccgCGTCTTTTCTGGCTAattttatgaa [BPP]
[GEA]
[1]
[2]
[3]
[4]
H-NS repressor hnsp hns 1292991 1293005 -40.0 gaattccttaCATTCCTGGCTATTGcacaactgaa [BPP]
[GEA]
[HIBSCS]
[5]
[1]
[2]
[3]
[4]
Fis activator hnsp hns 1293022 1293036 -71.0 ttattggcggCACAAAATAAAGAACaattttgaat [BPP] [1]
[3]
Fis activator hnsp hns 1293125 1293139 -174.0 atgtgacatgAATCAGGAAGTTTTAacctcacgtg [BPP] [1]
[3]
Fis activator hnsp hns 1293233 1293247 -282.0 ttattgcgacTGTTCTACTTTTCATcattcgctta [BPP] [1]
[3]
Fis activator hnsp hns 1293194 1293208 -243.0 ggaattctcgTAAACACAACTAATAcagaagactg [BPP] [1]
[3]
Fis activator hnsp hns 1293069 1293083 -118.0 tagggctataTGCCGCGTCTTTTCTggctaatttt [BPP] [1]
[3]
Fis activator hnsp hns 1292961 1292975 -10.0 ctgaatttaaGGCTCTATTATTACCtcaacaaacc [BPP] [1]
[3]
Fis activator hnsp hns 1292927 1292941 25.0 caccccaataTAAGTTTGAGATTACtacaatgagc [BPP] [1]
[3]
GadX activator hnsp hns         [GEA] [6]
CspA activator hnsp hns         [BPP] [7]
[3]
[8]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Falconi M., et al., 1996
[2] Falconi M., et al., 1993
[3] Giangrossi M., et al., 2001
[4] Ueguchi C., et al., 1993
[5] Dersch P., et al., 1993
[6] Hommais F., et al., 2004
[7] Brandi A., et al., 1994
[8] La Teana A., et al., 1991



Reference(s)    

 [1] Falconi M., Brandi A., La Teana A., Gualerzi CO., Pon CL., 1996, Antagonistic involvement of FIS and H-NS proteins in the transcriptional control of hns expression., Mol Microbiol 19(5):965-75

 [2] Falconi M., Higgins NP., Spurio R., Pon CL., Gualerzi CO., 1993, Expression of the gene encoding the major bacterial nucleotide protein H-NS is subject to transcriptional auto-repression., Mol Microbiol 10(2):273-82

 [3] Giangrossi M., Gualerzi CO., Pon CL., 2001, Mutagenesis of the downstream region of the Escherichia coli hns promoter., Biochimie 83(2):251-9

 [4] Ueguchi C., Kakeda M., Mizuno T., 1993, Autoregulatory expression of the Escherichia coli hns gene encoding a nucleoid protein: H-NS functions as a repressor of its own transcription., Mol Gen Genet 236(2-3):171-8

 [5] Dersch P., Schmidt K., Bremer E., 1993, Synthesis of the Escherichia coli K-12 nucleoid-associated DNA-binding protein H-NS is subjected to growth-phase control and autoregulation., Mol Microbiol 8(5):875-89

 [6] Hommais F., Krin E., Coppee JY., Lacroix C., Yeramian E., Danchin A., Bertin P., 2004, GadE (YhiE): a novel activator involved in the response to acid environment in Escherichia coli., Microbiology 150(Pt 1):61-72

 [7] Brandi A., Pon CL., Gualerzi CO., 1994, Interaction of the main cold shock protein CS7.4 (CspA) of Escherichia coli with the promoter region of hns., Biochimie 76(10-11):1090-8

 [8] La Teana A., Brandi A., Falconi M., Spurio R., Pon CL., Gualerzi CO., 1991, Identification of a cold shock transcriptional enhancer of the Escherichia coli gene encoding nucleoid protein H-NS., Proc Natl Acad Sci U S A 88(23):10907-11


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