RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CysB,H-NS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CysB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator CysB, positive transcriptional regulator for cysteine regulon
Gene name(s): cysB
Functional conformation(s): CysB-O-acetyl-L-serine , CysB-Thiosulfate , CysB-N-acetyl-L-serine , CysB-Sulphide , CysB
Coregulator(s): ArcA, Cbl, CpxR, CysB, FNR, H-NS, IHF, NtrC, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY CysB,H-NS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CysB activator H-NS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CysB-O-acetyl-L-serine activator cysPp cysM , cysA , cysW , cysU , cysP 2543601 2543642 -65.0 aaccaagttcTTATTCCCTTTTCAACTTCCAAATCACCAAACGGTATATAAAaccgttactc [BPP]
[GEA]
[1]
[2]
[3]
H-NS repressor cysPp cysM , cysA , cysW , cysU , cysP         [GEA] [4]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
Reference(s): [1] Lochowska A., et al., 2001
[2] Lochowska A., et al., 2004
[3] Otsuka J., et al., 1996
[4] White-Ziegler CA., et al., 2007



Reference(s)    

 [1] Lochowska A., Iwanicka-Nowicka R., Plochocka D., Hryniewicz MM., 2001, Functional dissection of the LysR-type CysB transcriptional regulator. Regions important for DNA binding, inducer response, oligomerization, and positive control., J Biol Chem 276(3):2098-107

 [2] Lochowska A., Iwanicka-Nowicka R., Zaim J., Witkowska-Zimny M., Bolewska K., Hryniewicz MM., 2004, Identification of activating region (AR) of Escherichia coli LysR-type transcription factor CysB and CysB contact site on RNA polymerase alpha subunit at the cysP promoter., Mol Microbiol 53(3):791-806

 [3] Otsuka J., Watanabe H., Mori KT., 1996, Evolution of transcriptional regulation system through promiscuous coupling of regulatory proteins with operons; suggestion from protein sequence similarities in Escherichia coli., J Theor Biol 178(2):183-204

 [4] White-Ziegler CA., Malhowski AJ., Young S., 2007, Human body temperature (37degrees C) increases the expression of iron, carbohydrate, and amino acid utilization genes in Escherichia coli K-12., J Bacteriol 189(15):5429-40


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