RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


CRP,FlhDC,GalR,GalS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsB, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalS Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalS, MglD
Gene name(s): galS
Functional conformation(s): GalS-D-galactose , GalS
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalR
Gene name(s): galR
Functional conformation(s): GalR , GalR-D-galactose
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FlhDC Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): FlhDC DNA-binding transcriptional dual regulator
Gene name(s): flhC, flhD
Functional conformation(s): FlhDC
Coregulator(s): ArcA, CRP, CsgD, DpiA, FNR, FhlA, Fis, FlhDC, GalR, GalS, GlpR, H-NS, IHF, MatA, ModE, NarL, NarP, NsrR, SutR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,FlhDC,GalR,GalS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator FlhDC repressor GalR repressor GalS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator mglBp mglC , mglA , mglB 2240597 2240618 -41.5 accgctttcaATCTGTGAGTGATTTCACAGTAtcttaacaat [AIBSCS]
[BCE]
[BPP]
[GEA]
[SM]
[1]
[2]
[3]
[4]
[5]
GalR repressor mglBp mglC , mglA , mglB 2240618 2240633 -59.5 aaatcaggcgATGTAACCGCTTTCAAtctgtgagtg [GEA]
[HIBSCS]
[6]
[3]
[7]
GalS repressor mglBp mglC , mglA , mglB 2240618 2240633 -59.5 aaatcaggcgATGTAACCGCTTTCAAtctgtgagtg [GEA]
[HIBSCS]
[6]
[8]
[3]
[9]
[7]
[4]
FlhDC repressor mglBp mglC , mglA , mglB         [GEA] [10]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[BCE] Binding of cellular extracts
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Hollands K., et al., 2007
[2] Jackson RJ., et al., 2008
[3] Semsey S., et al., 2007
[4] Weickert MJ., et al., 1993
[5] Zheng D., et al., 2004
[6] Geanacopoulos M., et al., 1997
[7] Weickert MJ., et al., 1993
[8] Otsuka J., et al., 1996
[9] Weickert MJ., et al., 1992
[10] Pruss BM., et al., 2001



Reference(s)    

 [1] Hollands K., Busby SJ., Lloyd GS., 2007, New targets for the cyclic AMP receptor protein in the Escherichia coli K-12 genome., FEMS Microbiol Lett 274(1):89-94

 [2] Jackson RJ., Binet MR., Lee LJ., Ma R., Graham AI., McLeod CW., Poole RK., 2008, Expression of the PitA phosphate/metal transporter of Escherichia coli is responsive to zinc and inorganic phosphate levels., FEMS Microbiol Lett 289(2):219-24

 [3] Semsey S., Krishna S., Sneppen K., Adhya S., 2007, Signal integration in the galactose network of Escherichia coli., Mol Microbiol 65(2):465-76

 [4] Weickert MJ., Adhya S., 1993, Control of transcription of gal repressor and isorepressor genes in Escherichia coli., J Bacteriol 175(1):251-8

 [5] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [6] Geanacopoulos M., Adhya S., 1997, Functional characterization of roles of GalR and GalS as regulators of the gal regulon., J Bacteriol 179(1):228-34

 [7] Weickert MJ., Adhya S., 1993, The galactose regulon of Escherichia coli., Mol Microbiol 10(2):245-51

 [8] Otsuka J., Watanabe H., Mori KT., 1996, Evolution of transcriptional regulation system through promiscuous coupling of regulatory proteins with operons; suggestion from protein sequence similarities in Escherichia coli., J Theor Biol 178(2):183-204

 [9] Weickert MJ., Adhya S., 1992, Isorepressor of the gal regulon in Escherichia coli., J Mol Biol 226(1):69-83

 [10] Pruss BM., Liu X., Hendrickson W., Matsumura P., 2001, FlhD/FlhC-regulated promoters analyzed by gene array and lacZ gene fusions., FEMS Microbiol Lett 197(1):91-7


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