RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


DnaA,LexA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
DnaA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): chromosomal replication initiator protein DnaA, chromosomal replication initiator protein/DNA-binding transcriptional dual regulator DnaA
Gene name(s): dnaA
Functional conformation(s): DnaA , DnaA-ATP
Coregulator(s): ArcA, ArgP, CRP, CytR, DnaA, FNR, Fis, H-NS, LexA, MarA, NrdR, PurR, Rob, SoxS, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
LexA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional repressor LexA, ExrA, Spr, Tsl, UmuA
Gene name(s): lexA
Functional conformation(s): LexA
Coregulator(s): ArcA, CRP, DinJ-YafQ, DnaA, LexA, NagC, RcdA, RcsB, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY DnaA,LexA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
DnaA repressor LexA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
LexA repressor recNp recN 2751727 2751746 -22.5 ccagcctcttTACTGTATATAAAACCAGTTtatactgtac [AIBSCS]
[BPP]
[GEA]
[1]
[2]
LexA repressor recNp recN 2751749 2751768 -0.5 aaccagtttaTACTGTACACAATAACAGTAatggtttttc [AIBSCS]
[BPP]
[GEA]
[1]
[2]
LexA repressor uvrBp3 uvrB 813120 813136 -24.5 tccactattcCTGTGGATAACCATGTGtattagagtt [BPP]
[GEA]
[ICA]
[SM]
[2]
DnaA-ATP repressor recNp recN 2751751 2751759 -4.0 ccagtttataCTGTACACAataacagtaa [GEA]
[ICA]
[2]
DnaA-ATP repressor recNp recN 2751730 2751738 -25.0 gcctctttacTGTATATAAaaccagttta [GEA]
[ICA]
[2]
DnaA-ATP repressor uvrBp2 uvrB 813330 813338 -128.0 gccgttgcttTGGGGATAAcccggtaagg [BPP]
[GEA]
[ICA]
[2]
LexA repressor uvrBp2 uvrB 813234 813250 -220.5 tattttttaaCTGGTTAGATAAATGCAatggcagtca [BPP]
[GEA]
[ICA]
[2]
DnaA-ATP repressor uvrBp3 uvrB 813133 813141 -15.0 tggataaccaTGTGTATTAgagttagaaa [BPP]
[GEA]
[ICA]
[2]
LexA repressor uvrBp2 uvrB 813287 813303 -167.5 tgccataaaaCTGTCATCACTCATCTTgacaaatgtt [BPP]
[GEA]
[ICA]
[2]
DnaA-ATP repressor uvrBp2 uvrB 813442 813450 -16.0 aactgtttttTTATCCAGTataatttgtt [BPP]
[GEA]
[ICA]
[2]
DnaA-ATP repressor uvrBp2 uvrB 813310 813318 -148.0 tcttgacaaaTGTTAAAAAagccgttgct [BPP]
[GEA]
[ICA]
[2]
LexA repressor uvrBp2 uvrB 813434 813450 -20.5 tggtgatgaaCTGTTTTTTTATCCAGTataatttgtt [BPP]
[GEA]
[HIBSCS]
[ICA]
[SM]
[3]
[4]
[2]
DnaA-ATP repressor uvrBp2 uvrB 813377 813385 -81.0 acagagtaaaTTTTGCTCAtgattgacag [BPP]
[GEA]
[ICA]
[2]
DnaA-ATP repressor uvrBp3 uvrB 813121 813129 -27.0 ccactattccTGTGGATAAccatgtgtat [BPP]
[GEA]
[ICA]
[SM]
[2]
DnaA-ATP repressor uvrBp3 uvrB 813107 813115 -41.0 ctggagacagTTATCCACTattcctgtgg [BPP]
[GEA]
[ICA]
[2]

Evidence: [AIBSCS] Automated inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
[ICA] Inferred by computational analysis
[SM] Site mutation
[HIBSCS] Human inference based on similarity to consensus sequences
Reference(s): [1] Rostas K., et al., 1987
[2] Wurihan., et al., 2018
[3] Nissenson RA., et al., 1985
[4] Sancar GB., et al., 1982



Reference(s)    

 [1] Rostas K., Morton SJ., Picksley SM., Lloyd RG., 1987, Nucleotide sequence and LexA regulation of the Escherichia coli recN gene., Nucleic Acids Res 15(13):5041-9

 [2] Wurihan., Gezi., Brambilla E., Wang S., Sun H., Fan L., Shi Y., Sclavi B., Morigen., 2018, DnaA and LexA Proteins Regulate Transcription of the uvrB Gene in Escherichia coli: The Role of DnaA in the Control of the SOS Regulon., Front Microbiol 9:1212

 [3] Nissenson RA., Strewler GJ., Williams RD., Leung SC., 1985, Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor., Cancer Res 45(11 Pt 1):5358-63

 [4] Sancar GB., Sancar A., Little JW., Rupp WD., 1982, The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoters., Cell 28(3):523-30


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