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FabR,FadR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
FabR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor FabR, YijC
Gene name(s): fabR
Functional conformation(s): FabR
Coregulator(s): FabR, FadR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FadR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FadR, Dec, Ole, OleR, ThdB
Gene name(s): fadR
Functional conformation(s): FadR , FadR-acyl-CoA
Coregulator(s): ArcA, CRP, DksA-ppGpp, FabR, FadR, Fis, HipB, IHF, IclR, OmpR, PhoP, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY FabR,FadR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
FabR repressor FadR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
FadR activator fabAp fabA 1016528 1016544 -38.0 gtttattccgAACTGATCGGACTTGTTcagcgtacac [BCE]
[GEA]
[HIBSCS]
[1]
[2]
[3]
[4]
FabR repressor fabAp fabA 1016509 1016526 -19.5 ggacttgttcAGCGTACACGTGTTAGCTatcctgcgtg [AIBSCS]
[BCE]
[BPP]
[GEA]
[HIBSCS]
[2]
[5]
[6]
FadR activator fabBp fabB 2441672 2441688 -39.0 tctattaaatGGCTGATCGGACTTGTTcggcgtacaa [BPP]
[GEA]
[HIBSCS]
[7]
[1]
[2]
FabR repressor fabBp fabB 2441653 2441670 -20.5 ggacttgttcGGCGTACAAGTGTACGCTattgtgcatt [BCE]
[BPP]
[GEA]
[HIBSCS]
[2]
[5]
[6]

Evidence: [BCE] Binding of cellular extracts
[GEA] Gene expression analysis
[HIBSCS] Human inference based on similarity to consensus sequences
[AIBSCS] Automated inference based on similarity to consensus sequences
[BPP] Binding of purified proteins
Reference(s): [1] DiRusso CC., et al., 1999
[2] Feng Y., et al., 2011
[3] Gui L., et al., 1996
[4] Henry MF., et al., 1992
[5] McCue L., et al., 2001
[6] Zhang YM., et al., 2002
[7] Campbell JW., et al., 2001



Reference(s)    

 [1] DiRusso CC., Black PN., Weimar JD., 1999, Molecular inroads into the regulation and metabolism of fatty acids, lessons from bacteria., Prog Lipid Res 38(2):129-97

 [2] Feng Y., Cronan JE., 2011, Complex binding of the FabR repressor of bacterial unsaturated fatty acid biosynthesis to its cognate promoters., Mol Microbiol 80(1):195-218

 [3] Gui L., Sunnarborg A., LaPorte DC., 1996, Regulated expression of a repressor protein: FadR activates iclR., J Bacteriol 178(15):4704-9

 [4] Henry MF., Cronan JE., 1992, A new mechanism of transcriptional regulation: release of an activator triggered by small molecule binding., Cell 70(4):671-9

 [5] McCue L., Thompson W., Carmack C., Ryan MP., Liu JS., Derbyshire V., Lawrence CE., 2001, Phylogenetic footprinting of transcription factor binding sites in proteobacterial genomes., Nucleic Acids Res 29(3):774-82

 [6] Zhang YM., Marrakchi H., Rock CO., 2002, The FabR (YijC) transcription factor regulates unsaturated fatty acid biosynthesis in Escherichia coli., J Biol Chem 277(18):15558-65

 [7] Campbell JW., Cronan JE., 2001, Escherichia coli FadR positively regulates transcription of the fabB fatty acid biosynthetic gene., J Bacteriol 183(20):5982-90


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