RegulonDB RegulonDB 10.6.3: Regulon Form
   
   


H-NS,IHF regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsB, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY H-NS,IHF Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
H-NS repressor IHF activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
H-NS repressor proVp3 proV , proW , proX 2804917 2804931 170.0 agaacaaattCTGGAAAAAACTGGGctatcgcttg [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804903 2804917 156.0 caaggactttCAAAAGAACAAATTCtggaaaaaac [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804877 2804891 130.0 cacagcgagcGTTCAAATATATCGAacaaggactt [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804847 2804861 100.0 aaaatctttaTAAAATATTTGGCGAgcatccacag [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804831 2804845 84.0 attaaattagAAATTAAAAATCTTTataaaatatt [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804819 2804833 72.0 tattgcatggCAATTAAATTAGAAAttaaaaatct [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804792 2804806 45.0 cgacatagacAAATAAAGGAATCTTtctattgcat [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804773 2804787 26.0 tttccattggGTAATATATCGACATagacaaataa [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804754 2804768 7.0 gggtagaaaaAAGTGACTATTTCCAttgggtaata [BPP] [1]
[2]
[3]
H-NS repressor proVp3 proV , proW , proX 2804715 2804729 -33.0 atttgccatcAGGGGTTGCCTCAGAttctcagtat [AIBSCS]
[BPP]
[GEA]
[1]
[2]
[3]
IHF activator proVp3 proV , proW , proX 2804730 2804744 -18.5 ttgcctcagaTTCTCAGTATGTTAGggtagaaaaa [BPP]
[GEA]
[4]
IHF activator proVp3 proV , proW , proX 2804887 2804902 140.0 gttcaaatatATCGAACAAGGACTTTcaaaagaaca [BPP]
[GEA]
[4]

Evidence: [BPP] Binding of purified proteins
[AIBSCS] Automated inference based on similarity to consensus sequences
[GEA] Gene expression analysis
Reference(s): [1] Lucht JM., et al., 1994
[2] Rajkumari K., et al., 2001
[3] Rajkumari K., et al., 1996
[4] Khodr A., et al., 2015



Reference(s)    

 [1] Lucht JM., Dersch P., Kempf B., Bremer E., 1994, Interactions of the nucleoid-associated DNA-binding protein H-NS with the regulatory region of the osmotically controlled proU operon of Escherichia coli., J Biol Chem 269(9):6578-8

 [2] Rajkumari K., Gowrishankar J., 2001, In vivo expression from the RpoS-dependent P1 promoter of the osmotically regulated proU operon in Escherichia coli and Salmonella enterica serovar Typhimurium: activation by rho and hns mutations and by cold stress., J Bacteriol 183(22):6543-50

 [3] Rajkumari K., Kusano S., Ishihama A., Mizuno T., Gowrishankar J., 1996, Effects of H-NS and potassium glutamate on sigmaS- and sigma70-directed transcription in vitro from osmotically regulated P1 and P2 promoters of proU in Escherichia coli., J Bacteriol 178(14):4176-81

 [4] Khodr A., Fairweather V., Bouffartigues E., Rimsky S., 2015, IHF is a trans-acting factor implicated in the regulation of the proU P2 promoter., FEMS Microbiol Lett 362(3):1-6


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