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DnaA,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
DnaA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): chromosomal replication initiator protein DnaA, chromosomal replication initiator protein/DNA-binding transcriptional dual regulator DnaA
Gene name(s): dnaA
Functional conformation(s): DnaA , DnaA-ATP
Coregulator(s): ArcA, ArgP, CRP, CytR, DnaA, FNR, Fis, H-NS, LexA, MarA, NrdR, PurR, Rob, SoxS, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY DnaA,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
DnaA dual ppGpp inhibition    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
DnaA-ATP repressor dnaAp2 recF , dnaN , dnaA 3883935 3883943 -57.0 aagtcctgtgGATAAATCGggaaaatctg [BPP]
[GEA]
[1]
[2]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883939 3883948 -61.0 ctggaaagtcCTGTGGATAAatcgggaaaa [BPP]
[SM]
[3]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883918 3883927 -40.0 tcgggaaaatCTGTGAGAAAcagaagatct [BPP]
[SM]
[3]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883929 3883938 -51.0 ctgtggataaATCGGGAAAAtctgtgagaa [BPP] [3]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883951 3883960 -73.0 acttagcgagTTCTGGAAAGtcctgtggat [BPP] [3]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883929 3883938 -51.0 ctgtggataaATCGGGAAAAtctgtgagaa [BPP] [3]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883951 3883960 -73.0 acttagcgagTTCTGGAAAGtcctgtggat [BPP] [3]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883939 3883948 -61.0 ctggaaagtcCTGTGGATAAatcgggaaaa [BPP]
[SM]
[3]
DnaA-ATP dual dnaAp2 recF , dnaN , dnaA 3883918 3883927 -40.0 tcgggaaaatCTGTGAGAAAcagaagatct [BPP]
[SM]
[3]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[SM] Site mutation
Reference(s): [1] Lee Y., et al., 1997
[2] Lee YS., et al., 1996
[3] Saggioro C., et al., 2013



Reference(s)    

 [1] Lee Y., Lee H., Yim J., Hwang D., 1997, The binding of two dimers of IciA protein to the dnaA promoter 1P element enhances the binding of RNA polymerase to the dnaA promoter 1P., Nucleic Acids Res 25(17):3486-9

 [2] Lee YS., Kim H., Hwang DS., 1996, Transcriptional activation of the dnaA gene encoding the initiator for oriC replication by IciA protein, an inhibitor of in vitro oriC replication in Escherichia coli., Mol Microbiol 19(2):389-96

 [3] Saggioro C., Olliver A., Sclavi B., 2013, Temperature-dependence of the DnaA-DNA interaction and its effect on the autoregulation of dnaA expression., Biochem J 449(2):333-41


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